[Changes of blood rheological properties and its correction under surgical and drug treatment in patients with phlegmons of maxillofacial area].

Blood theological properties in patients with phlegmons of maxillofacial area before treatment, immediately after surgical treatment and after surgical treatment combined with reamberin therapy were examined in the study. Negatively changed theological profile values somewhat improved after operation, mainly because of blood and serum viscosity decrease by 10-11% and blood transport capability enhancement. But significant positive macro- and microrheological changes was only received by surgical treatment combined with reamberin. Reed blood cells (RBC) incubation with reamberin proved direct microrheological effect of reamberin due to RBC deformability increase (by 10%, p < 0.05) and aggregation decrease (by 11%, p < 0.05). Positive theological changes associated with favorable clinical outcome.

[The role of factors determining rheological properties of blood in mechanisms of adaptation and damage in water imbalance].

The study was made of hematological, rheological and biochemical blood parameters of white male rats in daily intramuscular injection of 0.02 mcg of desmopressin and regular periodic hyperhydration of the organism achieved by introduction of 10% water loading within 3, 6, 9 days. The results evidence for significant action of desmopressin on liquid homeostasis not only by antidiuretic effects on the kidneys, by changing the condition of connecting tissue of the matrix as shown by a marked rise of acid GAG in plasm but also by influence on rheological properties of blood which is an important element of management of transcapillary exchange in tissue microregions.

Major alterations in body fluid status and blood rheology.

Since the dehydration causes a loss of body water, we studied the rheological properties of blood in the course of water deprivation. Subjects used in this study were 64 white male rats divided into 4 groups: control (n=19) and 3 experimental groups which underwent water deprivation for 3 days (n=15), 6 days (n=15) and 10 days (n=15). The results obtained indicate that under dehydration animals have higher blood and plasma viscosity and erythrocyte aggregation index than in the control group. After 3 days of dehydration these changes are due to the loss of intravascular water. The water deprivation for 10 days causes significant disturbances in blood composition as well as changes of red blood cell membrane properties whereas blood and plasma volume return to control values.

[Hemorheological profiles in patients with arterial hypertension and bronchial asthma]. / Gemoreologicheskie profili u patsientov s arterial'noí gipertenzieí i bronkhial'noí astmoí.

Hemorheological parameters were studied in patients with essential hypertension (men and women) and those with bronchial asthma. The rheological findings were established as a hemorheological profile. The latter is a set of macro- and microrheological parameters under various pathological conditions. The data show that blood viscosity was increased and correlate with blood pressure in hypertensive patients. There were more significant changes in the male populations of the two groups. The main cause of decreased blood fluidity and oxygen transport efficiency under these conditions is associated with hemoconcentration, elevated plasma levels of protein and increased plasma viscosity. The findings suggest that with the concept of a hemorheological profile one can correct rheological disturbances under various clinical conditions.

[State of the vascular bed of the lungs and pleura in congenital heart defects with hypovolemia of the lesser circulation]. / Sostoianie sosudistogo rusla legkikh i plevry pri vrozhdennykh porokakh serdtsa s gipovolemiei malogo kruga krovoobrashcheniia.

The status of the vessel bed of the lungs and pleura in congenital heart diseases with hypovolemia of the pulmonary circulation was studied. Morphological manifestations of adaptative changes in the vessels of microcirculation of these organs were found. The importance of the discovered changes in the maintenance of hemodynamic homeostasis under conditions of deficiency of blood inflow into the pulmonary artery is demonstrated.

[Pathomorphology of the vascular bed of the lungs and pleura in the presence of hypervolemia of the pulmonary circulation]. / Patomorfologiia sosudistogo rusla legkikh i plevry pri gipervolemii malogo kruga krovoobrashcheniia

Blood and lymphatic vessels of the lungs and the pleura in 23 infants aged below one year, who had died of congenital cardiac defects with hypervolemia of the lesser circulation (coarctation of the aorta, transposition of the major vessels, general arterial trunk in combination with septal defects, open arterial canal and other anomalies) and in 5 dogs with artificial anastomosis of Blalock (3), Cooley (I) and Pootts (I) were studied; In treatment of the materials various histological and histochemical methods, micropreparation and impregnation of total preparation according to Ranvier's and V. V; Kupriyanov's techniques were used. The results obtained showed that an excessive blood content of the lesser circulation was accompanied by onset in the vessels of the lungs and the pleura of various accomodative changes, which were particularly pronounced in the system of microcirculation. It was established that functional insufficiency of the adaptive mechanisms led to the "breakdown" of compensation, impairment of blood and lymph circulation in the terminal vascular bed of the lungs and to grave secondary alterations in the organ. It was shown that early correction of hypervolemia of the lesser circulation in the experiment brought about normalization of hemodynamics in the lungs and more or less full recovery of the structure of microvessels of the regional bed.

[Spontaneous migration of blood neutrophils in mixed leukocyte population and its changes under the effect of auto-plasma substances in various functional states]. / Spontannaia migratsiia neitrofilov krovi v smeshannoi populiatsii leikotsitov i ee izmeneniia pod vliianiem veshchest autoplasmy pri razlichnykh funktsional'nykh sostoianiiakh organizma.

Modified method for studies of leukocyte migration under agarose allows evaluating the spontaneous locomotion activity of cells and its changes under the effects of humoral factors accumulating in the blood in various pathological and extreme states. Trials of the method confirmed the possibility of its use for evaluation of locomotion changes depending on cell functions and mediated by plasma factors in various conditions.