Generation of a Hydrophobic Protrusion on Nanoparticles to Improve the Membrane-Anchoring Ability and Cellular Internalization.

Controlling the nanoparticle-cell membrane interaction to achieve easy and fast membrane anchoring and cellular internalization is of great importance in a variety of biomedical applications. Here we report a simple and versatile strategy to maneuver the nanoparticle-cell membrane interaction by creating a tunable hydrophobic protrusion on Janus particles through swelling-induced symmetry breaking. When the Janus particle contacts cell membrane, the protrusion will induce membrane wrapping, leading the particles to docking to the membrane, followed by drawing the whole particles into the cell. The efficiencies of both membrane anchoring and cellular internalization can be promoted by optimizing the size of the protrusion. In vitro, the Janus particles can quickly anchor to the cell membrane in 1 h and be internalized within 24 h, regardless of the types of cells involved. In vivo, the Janus particles can effectively anchor to the brain and skin tissues to provide a high retention in these tissues after intracerebroventricular, intrahippocampal, or subcutaneous injection. This strategy involving the creation of a hydrophobic protrusion on Janus particles to tune the cell-membrane interaction holds great potential in nanoparticle-based biomedical applications.

Catalyst development for O2-assisted oxidative dehydrogenation of propane to propylene.

O2-Assisted oxidative dehydrogenation of propane (O2-ODHP) could convert abundant shale gas into propylene as an important chemical raw material, meaning O2-ODHP has practical significance. Thermodynamically, high temperature is beneficial for O2-ODHP; however, high reaction temperature always causes the overoxidation of propylene, leading to a decline in its selectivity. In this regard, it is crucial to achieve low temperatures while maintaining high efficiency and selectivity during O2-ODHP. The use of catalytic technology provides more opportunities for achieving high-efficiency O2-ODHP under mild conditions. Up to now, many kinds of catalytic systems have been elaborately designed, including transition metal oxide catalysts (such as vanadium-based catalysts, molybdenum-based catalysts, etc.), transition metal-based catalysts (such as Pt nanoclusters), rare earth metal oxide catalysts (especially CeO2 related catalysts), and non-metallic catalysts (BN, other B-containing catalysts, and C-based catalysts). In this review, we have summarized the development progress of mainstream catalysts in O2-ODHP, aiming at providing a clear picture to the catalysis community and advancing this research field further.

Anti-Stress and Anti-ROS Effects of MnOx-Functionalized Thermosensitive Nanohydrogel Protect BMSCs for Intervertebral Disc Degeneration Repair.

Stem cell transplantation has been proven to be a promising strategy for intervertebral disc degeneration (IDD) repair. However, replicative senescence of bone marrow-derived mesenchymal stem cells (BMSCs), shear damage during direct injection, mechanical stress, and the reactive oxygen species (ROS)-rich microenvironment in degenerative intervertebral discs (IVDs) cause significant cellular damage and limit the therapeutic efficacy. Here, an injectable manganese oxide (MnOx)-functionalized thermosensitive nanohydrogel was proposed for BMSC transplantation for IDD therapy. The MnOx-functionalized thermosensitive nanohydrogel not only successfully protected BMSCs from shear force and mechanical stress before and after injection but also repaired the harsh high-ROS environment in degenerative IVDs, thus effectively increasing the viability of BMSCs and resident nucleus pulposus cells (NPCs). The MnOx-functionalized thermosensitive nanohydrogel provides mechanical protection for stem cells and helps to remove endogenous ROS, providing a promising stem cell delivery platform for the treatment of IDD. This article is protected by copyright. All rights reserved.

ent-Labdane diterpenes from the stems of Mallotus japonicus.

Eight new ent-labdane diterpenoids, mallonicusins A-H (1-8), were isolated from the stems of Mallotus japonicus. Their structures, including the absolute configurations, were determined by extensive analyses of spectroscopic data and the ECD spectra of the Pr(FOD)3 complex of substrates in CCl4. The absolute configuration of compound 1 was confirmed by single-crystal X-ray crystallography using Cu Kα radiation.

Recent advances on catalysts for photocatalytic selective hydrogenation of nitrobenzene to aniline.

Selective hydrogenation of nitrobenzene (SHN) is an important approach to synthesize aniline, an essential intermediate with extremely high research significance and value in the fields of textiles, pharmaceuticals and dyes. SHN reaction requires high temperature and high hydrogen pressure via the conventional thermal-driven catalytic process. On the contrary, photocatalysis provides an avenue to achieve high nitrobenzene conversion and high selectivity towards aniline at room temperature and low hydrogen pressure, which is in line with the sustainable development strategies. Designing efficient photocatalysts is a crucial step in SHN. Up to now, several photocatalysts have been explored for photocatalytic SHN, such as TiO2, CdS, Cu/graphene and Eosin Y. In this review, we divide the photocatalysts into three categories based on the characteristics of the light harvesting units, including semiconductors, plasmonic metal-based catalysts and dyes. The recent progress of the three categories of photocatalysts is summarized, the challenges and opportunities are pointed out and the future development prospects are described. It aims to give a clear picture to the catalysis community and stimulate more efforts in this research area.

Stress response to oxytetracycline and microplastic-polyethylene in wheat (Triticum aestivum L.) during seed germination and seedling growth stages.

Much efforts have been devoted to clarify the phytotoxicity of individual contaminants in plants, such as individual antibiotic and microplastic; however, little is known about the phytotoxicity of their combined exposure. Here, we investigated the effects of individual and combined exposure of wheat (Triticum aestivum L.) (Xiaoyan 22) to oxytetracycline (OTC) and polyethylene (PE) microplastics using physiological and metabolic profilings. During the seed germination stage, OTC induced phytotoxicity, as observed through the changes of root elongation, sprout length, fresh weight and the vitality index, with significant effect at the 50 and 150 mg·L-1 levels; the effect of PE microplastics depended on the OTC level in the combined exposure groups. During seedling cultivation, catalase (CAT) and ascorbate peroxidase (APX), as antioxidant enzyme indices, were sensitive to OTC exposure stress, although OTC was not determined in leaves. Untargeted metabolomics of wheat leaves revealed OTC concentration-, metabolite class- and PE-dependent metabolic responses. Dominant metabolites included carboxylic acids, alcohols, and amines in the control group and all treatment groups. Compared to only OTC treatment, PE reprogrammed carboxylic acid and alcohol profiles in combined exposure groups with obvious separation in PLS-DA. Combined exposure induced fewer metabolites than OTC exposure alone at the 5 and 50 mg·L-1 levels. The shared metabolite numbers were higher in the OTC groups than in the PE-OTC groups. Pathway enrichment analysis showed a drift in metabolic pathways between individual and combined exposure to OTC and PE, which included glyoxylate and dicarboxylate metabolism, amino acid metabolism and isoquinoline alkaloid biosynthesis. Among metabolites, aromatic acids and amino acids were more sensitive to combined exposure than individual exposure. These results contribute to clarifying the underlying mechanisms of phytotoxicity of individual and combined exposure to OTC and PE.

A minireview on the synthesis of single atom catalysts.

Single atom catalysis is a prosperous and rapidly growing research field, owing to the remarkable advantages of single atom catalysts (SACs), such as maximized atom utilization efficiency, tailorable catalytic activities as well as supremely high catalytic selectivity. Synthesis approaches play crucial roles in determining the properties and performance of SACs. Over the past few years, versatile methods have been adopted to synthesize SACs. Herein, we give a thorough and up-to-date review on the progress of approaches for the synthesis of SACs, outline the general principles and list the advantages and disadvantages of each synthesis approach, with the aim to give the readers a clear picture and inspire more studies to exploit novel approaches to synthesize SACs effectively.