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1.
Angew Chem Int Ed Engl ; 62(12): e202218621, 2023 Mar 13.
Artigo em Inglês | MEDLINE | ID: mdl-36658098

RESUMO

Solid-state lithium batteries are promising and safe energy storage devices for mobile electronics and electric vehicles. In this work, we report a facile in situ polymerization of 1,3-dioxolane electrolytes to fabricate integrated solid-state lithium batteries. The in situ polymerization and formation of solid-state dioxolane electrolytes on interconnected carbon nanotubes (CNTs) and active materials is the key to realizing a high-performance battery with excellent interfacial contact among CNTs, active materials and electrolytes. Therefore, the electrodes could be tightly integrated into batteries through the CNTs and electrolyte. Electrons/ions enable full access to active materials in the whole electrode. Electrodes with a low resistance of 4.5â€…Ω â–¡-1 and high lithium-ion diffusion efficiency of 2.5×10-11  cm2 s-1 can significantly improve the electrochemical kinetics. Subsequently, the batteries demonstrated high energy density, amazing charge/discharge rate and long cycle life.

2.
J Nanosci Nanotechnol ; 19(8): 4771-4777, 2019 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-30913785

RESUMO

Tungsten oxide nanoparticles with high dispersion supported on carbon nanotube (CNT) templates were fabricated by the liquid phase method. Given the isolation effects of the network from CNT bundles, the nano-size H2WO4 and WO3 can be obtained. The photodegradation ability of the WO3/CNTs was evaluated by methylene blue (MB). The degradation rate of MB can reach 94.7% for 30 min, which is superior to that of pure WO3 at 73.1% for 30 min. Furthermore, the degradation rate of the catalyst can reach 83.7% after recycling for five times, thus displaying the excellent stability of the photocatalyst. These results may be attributed to the highly dispersed WO3 nanoparticles and the suppression of electron-hole recombination by CNT templates. This study proves that WO3/CNT photocatalysts have potential applications in environmental and other related fields.

3.
BMC Cancer ; 14: 625, 2014 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-25164542

RESUMO

BACKGROUND: Dual anti-human epidermal growth factor receptor 2 (HER2) therapies have been shown to improve outcomes of HER2-positive breast cancer patients. We undertook a systematic review to compare treatment outcomes for patients who received single or combined anti-HER2 therapies. METHODS: We identified randomized control trials that compared dual anti-HER2 therapy and anti-HER2 monotherapy in patients with HER2-positive breast cancer. Outcomes included pathologic complete response (pCR), overall survival (OS), progression-free survival (PFS), and adverse events. Included in the analysis were seven trials that recruited 2,609 patients. RESULTS: In the neoadjuvant setting, the pooled pCR rate in the dual anti-HER2 therapy and monotherapy groups in combination with chemotherapy was 54.8% and 36%, respectively. This difference was statistically significant (relative risk, 1.56; 95% confidence interval (CI), 1.23-1.97; p < 0.001). In the metastatic setting, dual anti-HER2 therapy demonstrated significant benefits in both PFS (hazard ratio (HR), 0.71; 95% CI, 0.62-0.81; p < 0.001) and OS (HR, 0.68; 95% CI, 0.57-0.82; p < 0.001). Subgroup analyses indicated that the addition of chemotherapy to dual anti-HER2 therapy could greatly improve pCR in the neoadjuvant settings. However, in the metastatic setting, similar PFS and OS were found in patients receiving dual anti-HER2 therapy with or without chemotherapy. Dual anti-HER2 therapy was associated with more frequent adverse events than monotherapy, but no statistical differences were observed in cardiac toxicity. CONCLUSIONS: This systematic review provides a summary of all the data currently available, and confirms the benefits and risks of dual anti-HER2 therapy for HER2-positive breast cancer.


Assuntos
Antineoplásicos/efeitos adversos , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Neoplasias da Mama/tratamento farmacológico , Receptor ErbB-2/antagonistas & inibidores , Anticorpos Monoclonais Humanizados/efeitos adversos , Anticorpos Monoclonais Humanizados/uso terapêutico , Neoplasias da Mama/patologia , Quimioterapia Adjuvante , Feminino , Humanos , Lapatinib , Pessoa de Meia-Idade , Metástase Neoplásica , Quinazolinas/efeitos adversos , Quinazolinas/uso terapêutico , Ensaios Clínicos Controlados Aleatórios como Assunto , Trastuzumab , Resultado do Tratamento
4.
Anesthesiology ; 116(2): 406-14, 2012 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-22222470

RESUMO

BACKGROUND: Recent advances have indicated a complex interplay between the autonomic nervous system and the innate immune system. Targeting neural networks for the treatment of sepsis is being developed as a therapeutic strategy. Because electroacupuncture at select acupoints can modulate activities of the autonomic nervous system, we tested the hypothesis that electroacupuncture at specific acupoints could modulate systemic inflammatory responses and improve survival via its impact on the autonomic nervous system in a rat model of sepsis. METHODS: Sprague-Dawley male rats received electroacupuncture for 45 min before and at 1, 2, or 4 h after a lethal dose of intraperitoneal lipopolysaccharide injection (6 mg/kg). Outcomes included survival and systemic cytokine responses. Also, the possible roles of neural circuitry, including the hypothalamic-pituitary-adrenal axis and the autonomic nervous system, were evaluated. RESULTS: Electroacupuncture pretreatment at the Hegu acupoints significantly attenuate systemic inflammatory responses and improve survival rate from 20% to 80% in rats with lethal endotoxemia. Such a site-specific effect requires the activation of muscarinic receptors in the central nervous system, but not increasing central sympathetic tone. In the periphery synergistic, rather than independent, action of the sympathetic and parasympathetic systems is also necessary. CONCLUSIONS: Electroacupuncture pretreatment has a dramatic survival-enhancing effect in rats with lethal endotoxemia, which involves the activation of efferent neural circuits of the autonomic nervous system (e.g., cholinergic antiinflammatory pathway). This approach could be developed as a prophylactic treatment for sepsis or perioperative conditions related to excessive inflammation.


Assuntos
Sistema Nervoso Autônomo/fisiologia , Eletroacupuntura/métodos , Endotoxemia/mortalidade , Endotoxemia/terapia , Animais , Endotoxemia/fisiopatologia , Masculino , Rede Nervosa/fisiologia , Ratos , Ratos Sprague-Dawley , Taxa de Sobrevida/tendências
5.
ACS Appl Mater Interfaces ; 13(28): 33496-33504, 2021 Jul 21.
Artigo em Inglês | MEDLINE | ID: mdl-34228430

RESUMO

The use of magnetic particles and carbon materials, particularly those with compatible dielectric and magnetic loss, is crucial in managing microwave pollution. However, the mismatched impedance of currently available absorbers constrains their practical applications. Herein, we demonstrate the potential of a metal-organic framework (MOF)-derived composite whose impedance matching is optimized through spraying and immersion of MOF precursors in carbon nanotube socks followed by carbonization. The composite presents extremely strong microwave absorption with a reflection loss of -30 dB, a thin thickness of 1.5 mm, and a wide frequency bandwidth of 7.8 GHz. The excellent absorption can still be maintained even at a fairly low temperature of -40 °C. Such results are primarily attributed to the synergistic effect between the hierarchical architecture and multiple components that greatly optimizes the impedance matching. We believe that the composite is a promising microwave absorber that can help to solve the critical electromagnetic wave pollution.

6.
Adv Mater ; 33(4): e2006702, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33314412

RESUMO

Lithium (Li) metal is promising in the next-generation energy storage systems. However, its practical application is still hindered by the poor cycling performance and serious safety issues for the consequence of dendritic Li. Herein, a dendrite-free Li/carbon nanotube (CNT) hybrid is proposed, which is fabricated by direct coating molten Li on CNTs, for Li-metal batteries. The favorable thermodynamic and kinetic conditions are the powerful force to drive the rapid lift upwards and infusion of molten Li into CNTs network, which is the key to form a uniform metallic layer in Li/CNTs hybrid. The obtained hybrid indicates super-stable functions even at an ultrahigh current density of 40 mA cm-2 for 2000 cycles with a stripping/plating capacity of 2 mAh cm-2 in symmetric cells. Subsequently, this hybrid also demonstrates a significantly decreased resistance, excellent cycling stability at high current density and flexibility in the full Li-S battery. This work provides valuable concepts in fabricating Li anodes toward Li-metal batteries and beyond for their high-level services.

7.
Asian Pac J Cancer Prev ; 14(11): 6681-6, 2014 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-24377588

RESUMO

BACKGROUND: Fatal adverse events (FAEs) have been reported with sorafenib, a vascular endothelial growth factor receptor kinase inhibitor (VEGFR TKI). We here performed an up-to-date and detailed meta-analysis to determine the overall risk of FAEs associated with sorafenib. METHODS: Databases, including PubMed, Embase and Web of Science, and abstracts presented at the American Society of Clinical Oncology annual meetings were searched to identify relevant studies. Eligible studies included randomized controlled trials evaluating sorafenib effects in patients with all malignancies. Summary incidence rates, relative risks (RRs), and 95% confidence intervals (CIs) were calculated for FAEs. In addition, subgroup analyses were performed according to tumor type and therapy regimen. RESULTS: 13 trials recruiting 5,546 patients were included in our analysis. The overall incidence of FAEs with sorafenib was 1.99% (95%CI, 0.98-4.02%). Patients treated with sorafenib had a significantly increased risk of FAEs compared with patients treated with control medication, with an RR of 1.77 (95%CI 1.25-2.52, P=0.001). Risk varied with tumour type, but appeared independent of therapy regimen. A significantly increased risk of FAEs was observed in patients with lung cancer (RR 2.26; 95% CI 1.03-4.99; P= 0.043) and renal cancer (RR 1.84; 95% CI 1.15-2.94; P= 0.011). The most common causes of FAEs were hemorrhage (8.6%) and thrombus or embolism (4.9%). CONCLUSIONS: It is important for health care practitioners to be aware of the risks of FAEs associated with sorafenib, especially in patients with renal and lung cancer.


Assuntos
Antineoplásicos/efeitos adversos , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/mortalidade , Neoplasias/mortalidade , Niacinamida/análogos & derivados , Compostos de Fenilureia/efeitos adversos , Ensaios Clínicos como Assunto , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/etiologia , Humanos , Neoplasias/tratamento farmacológico , Niacinamida/efeitos adversos , Prognóstico , Fatores de Risco , Sorafenibe , Taxa de Sobrevida
8.
World J Gastroenterol ; 17(48): 5267-73, 2011 Dec 28.
Artigo em Inglês | MEDLINE | ID: mdl-22219595

RESUMO

AIM: To investigate the role of hepatic peroxisome proliferator-activated receptor-γ (PPAR-γ) in increased susceptibility to endotoxin-induced toxicity in rats with bile duct ligation during endotoxemia. METHODS: Male Sprague-Dawley rats were subjected to bile duct ligation (BDL). Sham-operated animals served as controls. DNA binding were determined by polymerase chain reaction, Western blotting analysis, and electrophoretic mobility shift assay, respectively. BDL and sham-operated rats received a non-lethal dose of intraperitoneal lipopolysaccharide (LPS) injection (3 mg/kg, i.p.). Additionally, the potential beneficial effects of the PPAR-γ agonist rosiglitazone were determined in BDL and sham-operated rats treated with a non-lethal dose of LPS. Survival was assessed in BDL rats treated with a non-lethal dose of LPS and in sham-operated rats treated at a lethal dose of LPS (6 mg/kg, i.p.). RESULTS: PPAR-γ activity in rats undergoing BDL was significantly lower than in the sham-controls. Hepatic PPAR-γ gene expression was downregulated at both the mRNA and protein levels. In a parallel group, serum levels of pro-inflammatory cytokines were nearly undetectable in the sham-operated rats. When challenged with a non-lethal dose of LPS (3 mg/kg), the BDL rats had approximately a 2.4-fold increase in serum IL-6, a 2.7 fold increase in serum TNF-α, 2.2-fold increase in serum IL-1 and 4.2-fold increase in serum ALT. The survival rate was significantly lower as compared with that in sham-operated group. Additionally, rosiglitazone significantly reduced the concentration of TNF-α, IL-1ß, IL-6 and ALT in sham-operated rats, but not in BDL rats, in response to LPS (3 mg/kg). Also, the survival was improved by rosiglitazone in sham-operated rats challenged with a lethal dose of LPS, but not in BDL rats, even with a non-lethal dose of LPS (3 mg/kg). CONCLUSION: Obstructive jaundice downregulates hepatic PPAR-γ expression, which in turn may contribute to hypersensitivity towards endotoxin.


Assuntos
Endotoxinas/farmacologia , Icterícia Obstrutiva/fisiopatologia , Fígado/efeitos dos fármacos , Fígado/metabolismo , PPAR gama/metabolismo , Peroxissomos/metabolismo , Alanina Transaminase/sangue , Animais , Ductos Biliares/cirurgia , Colestase/fisiopatologia , Endotoxemia/fisiopatologia , Hipoglicemiantes/farmacologia , Hipoglicemiantes/uso terapêutico , Interleucina-1/sangue , Interleucina-6/sangue , Icterícia Obstrutiva/tratamento farmacológico , Ligadura , Fígado/citologia , Masculino , PPAR gama/genética , Ratos , Ratos Sprague-Dawley , Rosiglitazona , Taxa de Sobrevida , Tiazolidinedionas/farmacologia , Tiazolidinedionas/uso terapêutico , Fator de Necrose Tumoral alfa/sangue
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