Detalhe da pesquisa
1.
Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP.
Immunity
; 52(2): 357-373.e9, 2020 02 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32049051
2.
A Real-Time Image-Based Efferocytosis Assay for the Discovery of Functionally Inhibitory Anti-MerTK Antibodies.
J Immunol
; 210(8): 1166-1176, 2023 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36881873
3.
Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy.
Proc Natl Acad Sci U S A
; 117(18): 9952-9963, 2020 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32345717
4.
PEGylation of anti-MerTK Antibody Modulates Ocular Biodistribution.
Bioconjug Chem
; 33(10): 1837-1851, 2022 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36153839
5.
The trimeric serine protease HtrA1 forms a cage-like inhibition complex with an anti-HtrA1 antibody.
Biochem J
; 472(2): 169-81, 2015 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26385991
6.
An anti-B7-H4 antibody-drug conjugate for the treatment of breast cancer.
Mol Pharm
; 12(6): 1717-29, 2015 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25853436
7.
Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth.
Cancer Cell
; 11(1): 53-67, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17222790
8.
A Bispecific Modeling Framework Enables the Prediction of Efficacy, Toxicity, and Optimal Molecular Design of Bispecific Antibodies Targeting MerTK.
AAPS J
; 26(1): 11, 2024 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38167740
9.
Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability.
MAbs
; 16(1): 2309685, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38356181
10.
Isoform-selective TGF-ß3 inhibition for systemic sclerosis.
Med
; 5(2): 132-147.e7, 2024 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38272035
11.
The Development and Characterization of a Highly Sensitive Mature TGFß3 Assay to Evaluate Anti-TGFß3 Target Engagement.
AAPS J
; 25(1): 21, 2023 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36703086
12.
A novel, label-free, pre-equilibrium assay to determine the association and dissociation rate constants of therapeutic antibodies on living cells.
Br J Pharmacol
; 2023 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37783572
13.
Anti-neuropilin-1 (MNRP1685A): unexpected pharmacokinetic differences across species, from preclinical models to humans.
Pharm Res
; 29(9): 2512-21, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22707361
14.
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis.
Nature
; 444(7122): 1083-7, 2006 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-17183323
15.
CLEC5a-directed bispecific antibody for effective cellular phagocytosis.
MAbs
; 14(1): 2040083, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35293277
16.
Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding.
EMBO J
; 26(23): 4902-12, 2007 Nov 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17989695
17.
Dramatic activation of an antibody by a single amino acid change in framework.
Sci Rep
; 11(1): 22365, 2021 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34785671
18.
Anti-LYPD1/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Ovarian Cancer.
Mol Cancer Ther
; 20(4): 716-725, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33536191
19.
TGFß2 and TGFß3 isoforms drive fibrotic disease pathogenesis.
Sci Transl Med
; 13(605)2021 08 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34349032
20.
Structural insight into distinct mechanisms of protease inhibition by antibodies.
Proc Natl Acad Sci U S A
; 104(50): 19784-9, 2007 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-18077410