Major pathological remissions in a patient with stage IIIA nonsmall cell lung cancer after neoadjuvant tislelizumab combined with chemotherapy: a case report and literature review.

INTRODUCTION: Currently, there are few reports of patients with locally advanced lung cancer achieving a clinical complete response by medical treatment. Preoperative neoadjuvant immunotherapy combined with chemotherapy is an option for patients with unresectable, locally advanced nonsmall cell lung cancer (NSCLC) which is of great potential, and may change traditional treatment paradigms. There are relatively few large-scale, high-quality randomized-controlled trials yet, and limitations such as short postoperative follow-up period and immature disease-free survival and overall survival data still persist. Thus, evidence-based medical evidence is urgently needed. It is worthy to explore the further treatment of patients who achieved complete response after initial treatment, though lacking of evidence by now. CASE PRESENTATION: We report a stage IIIA lung squamous cell carcinoma case who achieved a major pathologic remission after neoadjuvant treatment with tislelizumab and chemotherapy. CONCLUSION: Our case study contributes to the existing evidence on the feasibility, efficacy and safety of neoadjuvant immunotherapy combined with chemotherapy in locally advanced unresectable NSCLC.

Dynamic wetting of non-newtonian fluids: multicomponent molecular-kinetic approach.

Hydrodynamic models are generally applied to describe the dynamic wetting of newtonian or non-newtonian fluids on a solid surface. Conversely, the molecular-kinetic paradigm is only utilized for spreading newtonian fluids while considering the movement of a contact line as a molecular hopping process. This study extended the molecular-kinetic paradigm to the wetting behavior of non-newtonian fluids, while assuming there are n fluid components at the contact line regime interacting simultaneously with a solid surface during front movement. The limiting cases of the derived model at slow and fast moving speeds were discussed. Moreover, the derived model was validated based on dynamic contact angle data of three carboxymethylcellulose (CMC) aqueous solutions measured using the force-balance method. Best-fit parameters were used to interpret the wetting dynamics of CMC solutions.

Does macroscopic flow geometry influence wetting dynamic?

The macroscopic flow geometry has long been assumed to have little impact on dynamic wetting behavior of liquids on solid surfaces. This study experimentally studied both spontaneous spreading and forced wetting of several kinds of Newtonian and non-Newtonian fluids to study the effect of the macroscopic flow geometry on dynamic wetting. The relationship between the dynamic contact angle, θ(D), and the velocity of the moving contact line, U, indicates that the macroscopic flow geometry does not influence the advancing dynamic wetting behavior of Newtonian fluids, but does influence the advancing dynamic wetting behavior of non-Newtonian fluids, which had not been discovered before.

Spreading of completely wetting, non-Newtonian fluids with non-power-law rheology.

Spreading non-Newtonian liquids with non-power-law rheology on completely wetting surfaces are seldom investigated. This study assessed the wetting behavior of polydimethylsiloxane (PDMS), a Newtonian fluid, two carboxymethylcellulose (CMC) sodium solutions, a PDMS+2%w/w silica nanoparticle suspension and three polyethylene glycol (PEG400)+5-10%w/w silica nanoparticle suspensions (non-power-law fluids) on a mica surface. The theta(D)-U and R-t data for spreading drops of the six tested, non-power-law fluids can be described by power-law wetting models. We propose that this behavior is attributable to a uniform shear rate (a few tens to a few hundreds of s(-1)) distributed over the thin-film regime that controls spreading dynamics. Estimated film thickness was below the resolution of an optical microscope for direct observation. Approximating a general non-Newtonian fluid spreading as a power-law fluid greatly simplifies theoretical analysis and data interpretation.

Spreading dynamics of power-law fluid droplets.

This paper aims at providing a summary of the theoretical models available for non-Newtonian fluid spreading dynamics. Experimental findings and model predictions for a Newtonian fluid spreading test are briefly reviewed. Then how the complete wetting and partial wetting power-law fluids spread over a solid substrate is examined. The possible extension of Newtonian fluid models to power-law fluids is also discussed.