Detalhe da pesquisa
1.
M281, an anti-FcRn antibody, inhibits IgG transfer in a human ex vivo placental perfusion model.
Am J Obstet Gynecol
; 220(5): 498.e1-498.e9, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30849355
2.
Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity.
Proc Natl Acad Sci U S A
; 112(11): E1297-306, 2015 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25733881
3.
Pharmacokinetics and pharmacodynamics across infusion rates of intravenously administered nipocalimab: results of a phase 1, placebo-controlled study.
Front Neurosci
; 18: 1302714, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38362023
4.
Safety and Efficacy of Nipocalimab in Patients With Generalized Myasthenia Gravis: Results From the Randomized Phase 2 Vivacity-MG Study
Neurology
; 102(2): e207937, 2024 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38165333
5.
Live birth prevalence of hemolytic disease of the fetus and newborn in the United States from 1996 to 2010.
AJOG Glob Rep
; 3(2): 100203, 2023 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-37229151
6.
The small molecule TGF-ß signaling inhibitor SM16 synergizes with agonistic OX40 antibody to suppress established mammary tumors and reduce spontaneous metastasis.
Cancer Immunol Immunother
; 61(4): 511-21, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21971588
7.
Synthesis, SAR and biological evaluation of 1,6-disubstituted-1H-pyrazolo[3,4-d]pyrimidines as dual inhibitors of Aurora kinases and CDK1.
Bioorg Med Chem Lett
; 22(5): 2070-4, 2012 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22326168
8.
Structure-based design of 2,6,7-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines as Aurora kinases inhibitors.
Bioorg Med Chem Lett
; 22(12): 4033-7, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22607669
9.
Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I).
Bioorg Med Chem Lett
; 21(18): 5633-7, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21798738
10.
Pyrazolone based TGFbetaR1 kinase inhibitors.
Bioorg Med Chem Lett
; 20(1): 326-9, 2010 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19914068
11.
SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model.
Arterioscler Thromb Vasc Biol
; 28(4): 665-71, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18202322
12.
2-Aminoimidazoles inhibitors of TGF-beta receptor 1.
Bioorg Med Chem Lett
; 19(3): 912-6, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19135364
13.
An orally active small molecule TGF-beta receptor I antagonist inhibits the growth of metastatic murine breast cancer.
Anticancer Res
; 29(6): 2099-109, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19528470
14.
Transforming growth factor-beta receptor blockade augments the effectiveness of adoptive T-cell therapy of established solid cancers.
Clin Cancer Res
; 14(12): 3966-74, 2008 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18559619
15.
A novel small-molecule inhibitor of transforming growth factor beta type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection.
Cancer Res
; 67(5): 2351-9, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17332368
16.
M281, an Anti-FcRn Antibody: Pharmacodynamics, Pharmacokinetics, and Safety Across the Full Range of IgG Reduction in a First-in-Human Study.
Clin Pharmacol Ther
; 105(4): 1031-1039, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30402880
17.
Molecular profiling of rheumatoid arthritis patients reveals an association between innate and adaptive cell populations and response to anti-tumor necrosis factor.
Arthritis Res Ther
; 21(1): 216, 2019 10 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31647025
18.
Circulating Markers of Inflammation Persist in Children and Adults With Giant Aneurysms After Kawasaki Disease.
Circ Genom Precis Med
; 12(4): e002433, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30844302
19.
Small molecular inhibitor of transforming growth factor-beta protects against development of radiation-induced lung injury.
Int J Radiat Oncol Biol Phys
; 71(3): 829-37, 2008 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18411002
20.
Intracellular TGF-beta receptor blockade abrogates Smad-dependent fibroblast activation in vitro and in vivo.
J Invest Dermatol
; 126(8): 1733-44, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16741519