Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Scalable, Continuous Evolution of Genes at Mutation Rates above Genomic Error Thresholds.

Ravikumar, Arjun; Arzumanyan, Garri A; Obadi, Muaeen K A; Javanpour, Alex A; Liu, Chang C.

Cell ; 175(7): 1946-1957.e13, 2018 12 13.

Artigo em Inglês | MEDLINE | ID: mdl-30415839

2.

Discovery of VH domains that allosterically inhibit ENPP1.

Solomon, Paige E; Bracken, Colton J; Carozza, Jacqueline A; Wang, Haoqing; Young, Elizabeth P; Wellner, Alon; Liu, Chang C; Sweet-Cordero, E Alejandro; Li, Lingyin; Wells, James A.

Nat Chem Biol ; 20(1): 30-41, 2024 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-37400538

3.

Adding new chemistries to the genetic code.

Liu, Chang C; Schultz, Peter G.

Annu Rev Biochem ; 79: 413-44, 2010.

Artigo em Inglês | MEDLINE | ID: mdl-20307192

4.

Using continuous directed evolution to improve enzymes for plant applications.

García-García, Jorge D; Van Gelder, Kristen; Joshi, Jaya; Bathe, Ulschan; Leong, Bryan J; Bruner, Steven D; Liu, Chang C; Hanson, Andrew D.

Plant Physiol ; 188(2): 971-983, 2022 02 04.

Artigo em Inglês | MEDLINE | ID: mdl-34718794

5.

Lineage tracing and analog recording in mammalian cells by single-site DNA writing.

Loveless, Theresa B; Grotts, Joseph H; Schechter, Mason W; Forouzmand, Elmira; Carlson, Courtney K; Agahi, Bijan S; Liang, Guohao; Ficht, Michelle; Liu, Beide; Xie, Xiaohui; Liu, Chang C.

Nat Chem Biol ; 17(6): 739-747, 2021 06.

Artigo em Inglês | MEDLINE | ID: mdl-33753928

6.

Rapid generation of potent antibodies by autonomous hypermutation in yeast.

Wellner, Alon; McMahon, Conor; Gilman, Morgan S A; Clements, Jonathan R; Clark, Sarah; Nguyen, Kianna M; Ho, Ming H; Hu, Vincent J; Shin, Jung-Eun; Feldman, Jared; Hauser, Blake M; Caradonna, Timothy M; Wingler, Laura M; Schmidt, Aaron G; Marks, Debora S; Abraham, Jonathan; Kruse, Andrew C; Liu, Chang C.

Nat Chem Biol ; 17(10): 1057-1064, 2021 10.

Artigo em Inglês | MEDLINE | ID: mdl-34168368

7.

Sense and Sense Ability in a Synthetic Genetic Code.

Liu, Chang C.

N Engl J Med ; 385(11): 1045-1048, 2021 09 09.

Artigo em Inglês | MEDLINE | ID: mdl-34496180

8.

Characterization of a Sulfated Anti-HIV Antibody Using an Expanded Genetic Code.

Li, Xiang; Hitomi, Justin; Liu, Chang C.

Biochemistry ; 57(20): 2903-2907, 2018 05 22.

Artigo em Inglês | MEDLINE | ID: mdl-29738662

9.

A new path to tyrosine sulfation.

Liu, Chang C.

Nat Chem Biol ; 16(4): 365-366, 2020 04.

Artigo em Inglês | MEDLINE | ID: mdl-32198494

10.

An orthogonal DNA replication system in yeast.

Ravikumar, Arjun; Arrieta, Adrian; Liu, Chang C.

Nat Chem Biol ; 10(3): 175-7, 2014 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-24487693

11.

Biocontainment through reengineered genetic codes.

Ravikumar, Arjun; Liu, Chang C.

Chembiochem ; 16(8): 1149-51, 2015 May 26.

Artigo em Inglês | MEDLINE | ID: mdl-25917937

12.

An adaptor from translational to transcriptional control enables predictable assembly of complex regulation.

Liu, Chang C; Qi, Lei; Lucks, Julius B; Segall-Shapiro, Thomas H; Wang, Denise; Mutalik, Vivek K; Arkin, Adam P.

Nat Methods ; 9(11): 1088-94, 2012 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-23023598

13.

Toward an orthogonal central dogma.

Liu, Chang C; Jewett, Michael C; Chin, Jason W; Voigt, Chris A.

Nat Chem Biol ; 14(2): 103-106, 2018 01 16.

Artigo em Inglês | MEDLINE | ID: mdl-29337969

14.

Synthetic Epigenetics To Engineer Regulation.

Loveless, Theresa B; Liu, Chang C.

Biochemistry ; 58(12): 1558-1559, 2019 03 26.

Artigo em Inglês | MEDLINE | ID: mdl-30860818

15.

Biological applications of expanded genetic codes.

Li, Xiang; Liu, Chang C.

Chembiochem ; 15(16): 2335-41, 2014 Nov 03.

Artigo em Inglês | MEDLINE | ID: mdl-25171489

16.

Engineering naturally occurring trans-acting non-coding RNAs to sense molecular signals.

Qi, Lei; Lucks, Julius B; Liu, Chang C; Mutalik, Vivek K; Arkin, Adam P.

Nucleic Acids Res ; 40(12): 5775-86, 2012 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-22383579

17.

Accelerated evolution of chosen genes.

Williams, Rory L; Liu, Chang C.

Science ; 383(6681): 372-373, 2024 Jan 26.

Artigo em Inglês | MEDLINE | ID: mdl-38271527

18.

Continuous evolution of user-defined genes at 1-million-times the genomic mutation rate.

Rix, Gordon; Williams, Rory L; Spinner, Hansen; Hu, Vincent J; Marks, Debora S; Liu, Chang C.

bioRxiv ; 2023 Nov 14.

Artigo em Inglês | MEDLINE | ID: mdl-38014077

19.

An in silico method to assess antibody fragment polyreactivity.

Harvey, Edward P; Shin, Jung-Eun; Skiba, Meredith A; Nemeth, Genevieve R; Hurley, Joseph D; Wellner, Alon; Shaw, Ada Y; Miranda, Victor G; Min, Joseph K; Liu, Chang C; Marks, Debora S; Kruse, Andrew C.

Nat Commun ; 13(1): 7554, 2022 12 07.

Artigo em Inglês | MEDLINE | ID: mdl-36477674

20.

Protein evolution with an expanded genetic code.

Liu, Chang C; Mack, Antha V; Tsao, Meng-Lin; Mills, Jeremy H; Lee, Hyun Soo; Choe, Hyeryun; Farzan, Michael; Schultz, Peter G; Smider, Vaughn V.

Proc Natl Acad Sci U S A ; 105(46): 17688-93, 2008 Nov 18.

Artigo em Inglês | MEDLINE | ID: mdl-19004806

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