Detalhe da pesquisa
1.
Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in Mycobacterium abscessus.
Proc Natl Acad Sci U S A
; 121(2): e2314101120, 2024 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38165935
2.
Discovery and optimization of dihydropteridone derivatives as novel PLK1 and BRD4 dual inhibitor for the treatment of cancer.
Bioorg Med Chem
; 101: 117609, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38364599
3.
Stereoselective Synthesis of Substituted (Z)-N-Allyl Sulfonamides via a Palladium-Catalyzed Three-Component Tandem Reaction.
J Org Chem
; 88(7): 4162-4171, 2023 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36971317
4.
Based on 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474), design, synthesis and biological evaluation of novel PI3Kα selective inhibitors.
Bioorg Chem
; 130: 106211, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36343598
5.
Structure-based drug design, synthesis, and biological evaluation of novel 1,3,5-triazine or pyrimidine derivatives containing benzoyl hydrazine moiety as PI3Kα selective inhibitors.
Bioorg Chem
; 140: 106738, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37562315
6.
Model-Based Exposure-Response Assessment for Spectinamide 1810 in a Mouse Model of Tuberculosis.
Antimicrob Agents Chemother
; 65(11): e0174420, 2021 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34424046
7.
Lack of Specificity of Phenotypic Screens for Inhibitors of the Mycobacterium tuberculosis FAS-II System.
Antimicrob Agents Chemother
; 65(1)2020 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33139282
8.
Development of BODIPY FL Thalidomide As a High-Affinity Fluorescent Probe for Cereblon in a Time-Resolved Fluorescence Resonance Energy Transfer Assay.
Bioconjug Chem
; 31(11): 2564-2575, 2020 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33070611
9.
Synthesis and antiproliferative activity of sulfonamide-based peptidomimetic calpain inhibitors.
Bioorg Med Chem
; 28(9): 115433, 2020 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32199690
10.
Development and Characterization of a Dry Powder Formulation for Anti-Tuberculosis Drug Spectinamide 1599.
Pharm Res
; 36(9): 136, 2019 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31321552
11.
Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis.
Proc Natl Acad Sci U S A
; 113(26): 7148-53, 2016 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27307435
12.
Spectinamides are effective partner agents for the treatment of tuberculosis in multiple mouse infection models.
J Antimicrob Chemother
; 72(3): 770-777, 2017 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27999020
13.
Synthesis and evaluation of pretomanid (PA-824) oxazolidinone hybrids.
Bioorg Med Chem Lett
; 26(2): 388-391, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26711150
14.
Dendritic α-Fe2O3/TiO2 nanocomposites with improved visible light photocatalytic activity.
Phys Chem Chem Phys
; 18(13): 9176-85, 2016 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26974060
15.
Development of BODIPY FL vindoline as a novel and high-affinity pregnane X receptor fluorescent probe.
Bioconjug Chem
; 25(9): 1664-77, 2014 Sep 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25133934
16.
Characterization of spectinamide 1599 efficacy against different mycobacterial phenotypes.
Tuberculosis (Edinb)
; 140: 102342, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37120915
17.
Design and Synthesis of 1,3,5-Triazines or Pyrimidines Containing Dithiocarbamate Moiety as PI3Kα Selective Inhibitors.
ACS Med Chem Lett
; 14(9): 1266-1274, 2023 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37736169
18.
SNAP25 is a potential target for early stage Alzheimer's disease and Parkinson's disease.
Eur J Med Res
; 28(1): 570, 2023 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38053192
19.
Design, synthesis, and biological evaluation of novel dihydropteridone derivatives possessing oxadiazoles moiety as potent inhibitors of PLK1.
Eur J Med Chem
; 251: 115242, 2023 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36889251
20.
Development of a Minimalistic Physiologically Based Pharmacokinetic (mPBPK) Model for the Preclinical Development of Spectinamide Antibiotics.
Pharmaceutics
; 15(6)2023 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37376207