RESUMO
In the title compound, C(18)H(18)O(3)S, the C=C double bond exists in an E configuration and the dihedral angle between the two benzene rings is 11.74â (8)°. In the crystal, mol-ecules are linked into a three-dimensional network by C-Hâ¯O hydrogen bonds. The crystal structure is also stabilized by weak C-Hâ¯π inter-actions.
RESUMO
In the title compound, C(16)H(18)N(2)O(2)S, the piperidine ring adopts a chair conformation. The central 4-thia-zolidinone ring makes dihedral angles of 12.01â (7) and 51.42â (9)°, respectively, with the benzene ring and the least-squares plane of the piperidine ring. An intra-molecular C-Hâ¯S hydrogen bond stabilizes the mol-ecular structure and generates an S(6) ring motif. In the crystal, mol-ecules are linked into a tape along the c axis by inter-molecular C-Hâ¯O hydrogen bonds.
RESUMO
In the title compound, C(15)H(14)Cl(2)N(2)OS, the piperidine ring adopts a chair conformation. The dihedral angle between the thia-zolidine ring and the dichloro-benzene ring is 9.30â (4)°; this near coplanar conformation is stabilized by the formation of an intra-molecular C-Hâ¯S hydrogen bond, which generates an S(6) ring. In the crystal, mol-ecules are linked by C-Hâ¯O hydrogen bonds, forming [001] chains. Weak π-π inter-actions [centroid-centroid separation = 3.5460â (5)â Å] consolidate the structure.
RESUMO
The acid hydrazides (2) derived from ibuprofen and 4-methylthiophenyl acetic acids have been subjected to cyclization with carbon disulphide under basic conditions to yield 1,3,4-oxadiazol-2-thiones (3) which on aminomethylation with formaldehyde and secondary amines afforded a series of Mannich bases (4 and 5). Purity of the compounds has been confirmed by TLC. Structures of these compounds were established on the basis of elemental analyses and spectral studies. The newly synthesized compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic and antimicrobial activities.