Detalhe da pesquisa
1.
Synthesis and in vitro cytotoxicity of benzoxazole-based PPARα/γ antagonists in colorectal cancer cell lines.
Arch Pharm (Weinheim)
; : e2400086, 2024 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38807029
2.
Food Industry Byproducts as Starting Material for Innovative, Green Feed Formulation: A Sustainable Alternative for Poultry Feeding.
Molecules
; 27(15)2022 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35897911
3.
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE).
Molecules
; 27(3)2022 Jan 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-35164223
4.
Pharmacophore hybridization approach to discover novel pyrazoline-based hydantoin analogs with anti-tumor efficacy.
Bioorg Chem
; 107: 104527, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33317839
5.
Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors.
Bioorg Med Chem
; 28(3): 115257, 2020 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31874775
6.
Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors.
Int J Mol Sci
; 21(19)2020 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32987725
7.
Synthesis of novel benzothiazole amides: Evaluation of PPAR activity and anti-proliferative effects in paraganglioma, pancreatic and colorectal cancer cell lines.
Bioorg Med Chem Lett
; 29(16): 2302-2306, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31272790
8.
Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer's Disease.
Molecules
; 23(9)2018 Aug 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-30158491
9.
Dual targeting of cancer-related human matrix metalloproteinases and carbonic anhydrases by chiral N-(biarylsulfonyl)-phosphonic acids.
J Enzyme Inhib Med Chem
; 32(1): 1260-1264, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28948845
10.
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin.
Toxicol Appl Pharmacol
; 306: 36-46, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27377005
11.
An Effective Virtual Screening Protocol To Identify Promising p53-MDM2 Inhibitors.
J Chem Inf Model
; 56(6): 1216-27, 2016 06 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27269808
12.
Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity.
J Enzyme Inhib Med Chem
; 31(sup4): 25-37, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27556138
13.
LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties.
J Biol Chem
; 289(10): 6908-6920, 2014 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24451380
14.
Structural basis of the transactivation deficiency of the human PPARγ F360L mutant associated with familial partial lipodystrophy.
Acta Crystallogr D Biol Crystallogr
; 70(Pt 7): 1965-76, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25004973
15.
Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII.
Bioorg Med Chem Lett
; 24(8): 1941-3, 2014 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24650641
16.
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors.
Bioorg Med Chem Lett
; 24(12): 2617-20, 2014 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24813742
17.
A chemical modification of a peroxisome proliferator-activated receptor pan agonist produced a shift to a new dual alpha/gamma partial agonist endowed with mitochondrial pyruvate carrier inhibition and antidiabetic properties.
Eur J Med Chem
; 275: 116567, 2024 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38865743
18.
Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors.
Bioorg Med Chem
; 21(21): 6456-65, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24071448
19.
Biological Screening and Crystallographic Studies of Hydroxy γ-Lactone Derivatives to Investigate PPARγ Phosphorylation Inhibition.
Biomolecules
; 13(4)2023 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37189440
20.
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition.
J Med Chem
; 66(5): 3566-3587, 2023 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36790935