Detalhe da pesquisa
1.
Discovery of a CCR2-targeting pepducin therapy for chronic pain.
Pharmacol Res
; : 107242, 2024 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38823470
2.
Mechanistic insights into the role of the chemokine CCL2/CCR2 axis in dorsal root ganglia to peripheral inflammation and pain hypersensitivity.
J Neuroinflammation
; 18(1): 79, 2021 Mar 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33757529
3.
The P2Y6 receptor signals through Gαq /Ca2+ /PKCα and Gα13 /ROCK pathways to drive the formation of membrane protrusions and dictate cell migration.
J Cell Physiol
; 235(12): 9676-9690, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32420639
4.
Cell-penetrating pepducins targeting the neurotensin receptor type 1 relieve pain.
Pharmacol Res
; 155: 104750, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32151680
5.
The hypotensive effect of activated apelin receptor is correlated with ß-arrestin recruitment.
Pharmacol Res
; 131: 7-16, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29530600
6.
Chemical space screening around Phe3 in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings.
Bioorg Med Chem Lett
; 28(13): 2320-2323, 2018 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29853330
7.
Structure-activity relationship of novel macrocyclic biased apelin receptor agonists.
Org Biomol Chem
; 15(2): 449-458, 2017 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27924341
8.
Functional inhibition of chemokine receptor CCR2 by dicer-substrate-siRNA prevents pain development.
Mol Pain
; 122016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27306408
9.
The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the neurotensin receptor type 2.
Bioorg Med Chem Lett
; 25(10): 2060-4, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25881832
10.
Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2.
Bioorg Med Chem Lett
; 25(2): 292-6, 2015 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25499438
11.
Stability and degradation patterns of chemically modified analogs of apelin-13 in plasma and cerebrospinal fluid.
Biopolymers
; 102(4): 297-303, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24728860
12.
Corrigendum to "Chemical space screening around Phe3 in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings" [Bioorg. Med. Chem. Lett. 28(13) (2018) 2320-2323].
Bioorg Med Chem Lett
; 28(20): 3418, 2018 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30195888
13.
Ligand-dependent intracellular trafficking of the G protein-coupled P2Y6 receptor.
Biochim Biophys Acta Mol Cell Res
; 1870(5): 119476, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37059189
14.
Signaling Modulation via Minimal C-Terminal Modifications of Apelin-13.
ACS Pharmacol Transl Sci
; 6(2): 290-305, 2023 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36798478
15.
Size-Reduced Macrocyclic Analogues of [Pyr1]-apelin-13 Showing Negative Gα12 Bias Still Produce Prolonged Cardiac Effects.
J Med Chem
; 65(1): 531-551, 2022 01 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34982553
16.
Structural insight into apelin receptor-G protein stoichiometry.
Nat Struct Mol Biol
; 29(7): 688-697, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35817871
17.
Design, Structural Optimization, and Characterization of the First Selective Macrocyclic Neurotensin Receptor Type 2 Non-opioid Analgesic.
J Med Chem
; 64(4): 2110-2124, 2021 02 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33538583
18.
Pharmacodynamic and pharmacokinetic profiles of a neurotensin receptor type 2 (NTS2) analgesic macrocyclic analog.
Biomed Pharmacother
; 141: 111861, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-34229249
19.
Elabela Protects Spontaneously Hypertensive Rats From Hypertension and Cardiorenal Dysfunctions Exacerbated by Dietary High-Salt Intake.
Front Pharmacol
; 12: 709467, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34385922
20.
Metabolically stable neurotensin analogs exert potent and long-acting analgesia without hypothermia.
Behav Brain Res
; 405: 113189, 2021 05 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33607165