Detalhe da pesquisa
1.
Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors.
Molecules
; 24(7)2019 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30959951
2.
Structural Comparison of Enterococcus faecalis and Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities.
Molecules
; 24(7)2019 Mar 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-30935102
3.
Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth.
Molecules
; 24(19)2019 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31561530
4.
Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase.
Proc Natl Acad Sci U S A
; 108(34): E542-9, 2011 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-21795601
5.
The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents.
Eur J Med Chem
; 264: 115946, 2024 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38043491
6.
High-Throughput Phenotypic Screening and Machine Learning Methods Enabled the Selection of Broad-Spectrum Low-Toxicity Antitrypanosomatidic Agents.
J Med Chem
; 66(22): 15230-15255, 2023 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37921561
7.
The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism.
Acta Crystallogr D Biol Crystallogr
; 68(Pt 9): 1232-41, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22948925
8.
Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1.
J Med Chem
; 65(13): 9011-9033, 2022 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35675511
9.
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth.
Elife
; 112022 12 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36475542
10.
Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases.
Pharmaceuticals (Basel)
; 14(12)2021 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34959646
11.
Ligand-based virtual screening and ADME-tox guided approach to identify triazolo-quinoxalines as folate cycle inhibitors.
Bioorg Med Chem
; 18(22): 7773-85, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20951595
12.
Microbiota of sliced cooked ham packaged in modified atmosphere throughout the shelf life: Microbiota of sliced cooked ham in MAP.
Int J Food Microbiol
; 289: 200-208, 2019 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30268907
13.
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections.
J Med Chem
; 62(8): 3989-4012, 2019 04 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30908048
14.
SAR Studies and Biological Characterization of a Chromen-4-one Derivative as an Anti-Trypanosoma brucei Agent.
ACS Med Chem Lett
; 10(4): 528-533, 2019 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30996791
15.
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics.
Eur J Med Chem
; 183: 111676, 2019 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31542713
16.
Aryl thiosemicarbazones for the treatment of trypanosomatidic infections.
Eur J Med Chem
; 146: 423-434, 2018 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29407968
17.
Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth.
J Med Chem
; 61(16): 7374-7380, 2018 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30035541
18.
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery.
ACS Omega
; 2(9): 5666-5683, 2017 Sep 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-28983525
19.
Comparing Drug Images and Repurposing Drugs with BioGPS and FLAPdock: The Thymidylate Synthase Case.
ChemMedChem
; 11(15): 1653-66, 2016 08 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27404817
20.
X-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitors.
Eur J Med Chem
; 123: 649-664, 2016 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27517810