1.
Bioorg Med Chem Lett
; 14(22): 5551-4, 2004 Nov 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15482922
RESUMO
Structurally simplified macrocyclic ketone analogues of halichondrin B were prepared by total synthesis and found to retain the potent cell growth inhibitory activity in vitro, stability in mouse serum, and in vivo efficacy of the natural product.