Detalhe da pesquisa
1.
Reducing the antigen-independent toxicity of antibody-drug conjugates by minimizing their non-specific clearance through PEGylation.
Toxicol Appl Pharmacol
; 392: 114932, 2020 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32109510
2.
An in Vitro Assay Using Cultured Kupffer Cells Can Predict the Impact of Drug Conjugation on in Vivo Antibody Pharmacokinetics.
Mol Pharm
; 17(3): 802-809, 2020 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31976667
3.
Structure-activity relationships of tubulysin analogues.
Bioorg Med Chem Lett
; 30(14): 127241, 2020 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32527543
4.
The Methylene Alkoxy Carbamate Self-Immolative Unit: Utilization for the Targeted Delivery of Alcohol-Containing Payloads with Antibody-Drug Conjugates.
Angew Chem Int Ed Engl
; 55(28): 7948-51, 2016 07 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27198854
5.
SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML.
Blood
; 122(8): 1455-63, 2013 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23770776
6.
A potent anti-CD70 antibody-drug conjugate combining a dimeric pyrrolobenzodiazepine drug with site-specific conjugation technology.
Bioconjug Chem
; 24(7): 1256-63, 2013 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-23808985
7.
SGN-B6A: A New Vedotin Antibody-Drug Conjugate Directed to Integrin Beta-6 for Multiple Carcinoma Indications.
Mol Cancer Ther
; 22(12): 1444-1453, 2023 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37619980
8.
Improving Antibody-Tubulysin Conjugates through Linker Chemistry and Site-Specific Conjugation.
ChemMedChem
; 16(7): 1077-1081, 2021 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33369163
9.
Novel Auristatins with High Bystander and Cytotoxic Activities in Drug Efflux-positive Tumor Models.
Mol Cancer Ther
; 20(2): 320-328, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33288628
10.
Snap-to-it probes: chelate-constrained nucleobase oligomers with enhanced binding specificity.
Nucleic Acids Res
; 36(11): 3522-30, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18448470
11.
A coiled-coil masking domain for selective activation of therapeutic antibodies.
Nat Biotechnol
; 37(7): 761-765, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31133742
12.
Glucuronide-Linked Antibody-Tubulysin Conjugates Display Activity in MDR+ and Heterogeneous Tumor Models.
Mol Cancer Ther
; 17(8): 1752-1760, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29866744
13.
Targeted Delivery of Cytotoxic NAMPT Inhibitors Using Antibody-Drug Conjugates.
Mol Cancer Ther
; 17(12): 2633-2642, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30242091
14.
Optimization of a PEGylated Glucuronide-Monomethylauristatin E Linker for Antibody-Drug Conjugates.
Mol Cancer Ther
; 16(1): 116-123, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28062707
15.
Antibody-conjugated drug assay for protease-cleavable antibody-drug conjugates.
Bioanalysis
; 8(1): 55-63, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26647801
16.
Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models.
Cancer Res
; 76(9): 2710-9, 2016 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26921341
17.
Development of Novel Quaternary Ammonium Linkers for Antibody-Drug Conjugates.
Mol Cancer Ther
; 15(5): 938-45, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26944920
18.
Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index.
Nat Biotechnol
; 33(7): 733-5, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-26076429
19.
Estradiol metabolites as isoform-specific inhibitors of human glutathione S-transferases.
Chem Biol Interact
; 151(1): 21-32, 2004 Dec 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-15607759
20.
Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates.
Nat Biotechnol
; 32(10): 1059-62, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25194818