Detalhe da pesquisa
1.
Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities.
Bioorg Med Chem Lett
; 25(17): 3716-20, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26212775
2.
Effect of anchoring 4-anilidopiperidines to opioid peptides.
Bioorg Med Chem Lett
; 23(11): 3434-7, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23623418
3.
Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities.
Bioorg Med Chem Lett
; 23(17): 4975-8, 2013 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23899615
4.
New potent biphalin analogues containing p-fluoro-L-phenylalanine at the 4,4' positions and non-hydrazine linkers.
Amino Acids
; 40(5): 1503-11, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20924622
5.
Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain.
Bioorg Med Chem Lett
; 20(14): 4080-4, 2010 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20547453
6.
Synthesis and evaluation of new endomorphin analogues modified at the Pro(2) residue.
Bioorg Med Chem Lett
; 19(15): 4115-8, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19560919
7.
The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.
Bioorg Med Chem
; 17(20): 7337-43, 2009 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19762245
8.
A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
J Med Chem
; 51(5): 1369-76, 2008 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-18266313
9.
Structure-activity relationships of bifunctional cyclic disulfide peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors.
Peptides
; 29(8): 1413-23, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18502541
10.
Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis.
J Med Chem
; 50(13): 3138-42, 2007 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17539621
11.
Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors.
J Med Chem
; 50(1): 165-8, 2007 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-17201419
12.
Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists.
J Med Chem
; 50(12): 2779-86, 2007 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17516639
13.
Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors.
J Med Chem
; 50(22): 5528-32, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17927164
14.
Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors.
J Med Chem
; 49(10): 2868-75, 2006 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-16686530
15.
Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists.
J Med Chem
; 49(5): 1773-80, 2006 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-16509592
16.
4-{N-[2-(1,3-Dioxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl]anilino}-1-phenethylpiperidinium chloride methanol disolvate.
Acta Crystallogr Sect E Struct Rep Online
; 62(7): o2815-o2816, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17268579
17.
An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons.
Mol Pain
; 1: 29, 2005 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-16191203
18.
Novel analogues of bifunctional ligands for opioid and melanocortin 4 receptor.
Adv Exp Med Biol
; 611: 195-6, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19400157
19.
Development of mu/delta opioid ligands: enkephalin analogues containing 4-anilidopiperidine moiety.
Adv Exp Med Biol
; 611: 517-8, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19400292
20.
Novel bifunctional peptides as opioid agonists and NK-1 antagonists.
Adv Exp Med Biol
; 611: 537-8, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19400302