Detalhe da pesquisa
1.
Fostemsavir and ethinyl estradiol drug interaction: Clinical recommendations for co-administration.
HIV Med
; 24(5): 580-587, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36372442
2.
Pharmacokinetics of Temsavir, the Active Moiety of the HIV-1 Attachment Inhibitor Prodrug, Fostemsavir, Coadministered with Cobicistat, Etravirine, Darunavir/Cobicistat, or Darunavir/Ritonavir with or without Etravirine in Healthy Participants.
Antimicrob Agents Chemother
; 66(4): e0225121, 2022 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35315687
3.
Pharmacokinetics, metabolism and excretion of radiolabeled fostemsavir administered with or without ritonavir in healthy male subjects.
Xenobiotica
; 52(6): 541-554, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-36083110
4.
Methadone and buprenorphine pharmacokinetics and pharmacodynamics when coadministered with fostemsavir to opioid-dependent, human immunodeficiency virus seronegative participants.
Br J Clin Pharmacol
; 85(8): 1771-1780, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30980734
5.
Safety, pharmacokinetics and pharmacological effects of the selective androgen receptor modulator, GSK2881078, in healthy men and postmenopausal women.
Br J Clin Pharmacol
; 83(10): 2179-2194, 2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28449232
6.
Darapladib, a lipoprotein-associated phospholipase A2 inhibitor, in diabetic macular edema: a 3-month placebo-controlled study.
Ophthalmology
; 122(5): 990-6, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25749297
7.
The pharmacokinetics and safety of darapladib in subjects with severe renal impairment.
Br J Clin Pharmacol
; 80(4): 654-61, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25953363
8.
Disposition and metabolism of darapladib, a lipoprotein-associated phospholipase A2 inhibitor, in humans.
Drug Metab Dispos
; 42(3): 415-30, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24378325
9.
An effect of moderate hepatic impairment on the pharmacokinetics and safety of darapladib.
Br J Clin Pharmacol
; 78(5): 1014-21, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24938621
10.
A Quantitative Clinical Pharmacology-Based Framework For Model-Informed Vaccine Development.
J Pharm Sci
; 113(1): 22-32, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37924975
11.
Population Pharmacokinetics of Bepirovirsen in Healthy Participants and Participants with Chronic Hepatitis B Virus Infection: Results from Phase 1, 2a, and 2b Studies.
Infect Dis Ther
; 2024 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38796564
12.
Considerations for Industry-Preparing for the FDA Model-Informed Drug Development (MIDD) Paired Meeting Program.
Clin Pharmacol Ther
; 2024 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38519861
13.
Model-Based Dose Selection of Fostemsavir for Pediatric Populations With Multidrug-Resistant HIV-1 and Relative Bioavailability Assessment in Healthy Adults.
Clin Pharmacol Drug Dev
; 12(10): 991-1000, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37329260
14.
Opportunities and Challenges of Disease Progression Modeling in Drug Development - An IQ Perspective.
Clin Pharmacol Ther
; 114(2): 266-274, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36802040
15.
Evaluation of the pharmacokinetic drug-drug interaction between the antiretroviral agents fostemsavir and maraviroc: a single-sequence crossover study in healthy participants.
HIV Res Clin Pract
; 23(1): 1-8, 2021 12 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35285786
16.
Effect of Renal and Hepatic Impairment on the Pharmacokinetics of Temsavir, the Active Moiety of Fostemsavir.
J Clin Pharmacol
; 61(7): 939-953, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33368327
17.
Effects of rifampicin (rifampin) on the pharmacokinetics and safety of ambrisentan in healthy subjects: a single-sequence, open-label study.
Clin Drug Investig
; 30(12): 875-885, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-20923245
18.
Effects of Temsavir, Active Moiety of Antiretroviral Agent Fostemsavir, on QT Interval: Results From a Phase I Study and an Exposure-Response Analysis.
Clin Transl Sci
; 13(4): 769-776, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32027457
19.
Effect of ketoconazole on the pharmacokinetic profile of ambrisentan.
J Clin Pharmacol
; 49(6): 719-24, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19389876
20.
A Phase 1 Randomized, Placebo-Controlled Study Assessing the Pharmacokinetics, Safety, and Tolerability of Retosiban in Healthy, Nonpregnant Japanese Subjects.
Clin Pharmacol Drug Dev
; 7(1): 59-66, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28419732