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1.
Exp Mol Pathol ; 110: 104274, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31226265

RESUMO

The food-borne liver trematode Opisthorchis felineus causes severe liver damage, including fibrosis. This study shows a comparison of the characteristics between cholangiofibrosis and periductal fibrosis in infected people and in the golden hamster as an experimental model. Comparative evaluation was carried out regarding collagen composition, the number of basic-producing cells, and extracellular-matrix degradation. The results revealed that characteristics of chronic opisthorchiasis due to O. felineus infection in humans and in Syrian hamsters are similar and include well-pronounced development of fibrotic complications in the liver parenchyma. Besides, a difference in fibrogenesis development was demonstrated between chronic O. felineus infection and noninfectious cholecystitis. In this study, we for the first time compared fibrogenesis between humans and model animals against the background of chronic O. felineus infection.


Assuntos
Cirrose Hepática/parasitologia , Mesocricetus/parasitologia , Opistorquíase/parasitologia , Opisthorchis/fisiologia , Animais , Doença Crônica , Colágeno Tipo I/metabolismo , Cricetinae , Modelos Animais de Doenças , Humanos , Fígado/metabolismo , Fígado/parasitologia , Fígado/patologia , Cirrose Hepática/metabolismo , Mesocricetus/metabolismo , Opistorquíase/metabolismo
2.
Carcinogenesis ; 38(9): 929-937, 2017 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-28910999

RESUMO

The liver fluke Opisthorchis felineus is a member of the triad of epidemiologically relevant species of the trematode family Opisthorchiidae, and the causative agent of opisthorchiasis felinea over an extensive range that spans regions of Eurasia. The International Agency for Research on Cancer classifies the infection with the liver flukes Opisthorchis viverrini and Clonorchis sinensis as group 1 agents and a major risk factor for cholangiocarcinoma. However, the carcinogenic potential of the infection with O. felineus is less clear. Here, we present findings that support the inclusion of O. felineus in the Group 1 list of biological carcinogens. Two discrete lines of evidence support the notion that infection with this liver fluke is carcinogenic. First, novel oxysterol-like metabolites detected by liquid chromatography-mass spectroscopy in the egg and adult developmental stages of O. felineus, and in bile, sera, and urine of liver fluke-infected hamsters exhibited marked similarity to oxysterol-like molecules known from O. viverrini. Numerous oxysterols and related DNA-adducts detected in the liver fluke eggs and in bile from infected hamsters suggested that infection-associated oxysterols induced chromosomal lesions in host cells. Second, histological analysis of liver sections from hamsters infected with O. felineus confirmed portal area enlargement, inflammation with severe periductal fibrosis and changes in the epithelium of the biliary tract characterized as biliary intraepithelial neoplasia, BilIN. The consonance of these biochemical and histopathological changes revealed that O. felineus infection in this rodent model induced precancerous lesions conducive to malignancy.


Assuntos
Neoplasias dos Ductos Biliares/parasitologia , Ductos Biliares Intra-Hepáticos/parasitologia , Carcinogênese , Colangiocarcinoma/parasitologia , Opistorquíase/complicações , Opisthorchis/patogenicidade , Animais , Neoplasias dos Ductos Biliares/sangue , Neoplasias dos Ductos Biliares/patologia , Neoplasias dos Ductos Biliares/urina , Biomarcadores Tumorais/sangue , Biomarcadores Tumorais/urina , Biópsia , Colangiocarcinoma/sangue , Colangiocarcinoma/patologia , Colangiocarcinoma/urina , Cromatografia Líquida de Alta Pressão , Cricetinae , Adutos de DNA/sangue , Adutos de DNA/urina , Humanos , Masculino , Neoplasias Experimentais/sangue , Neoplasias Experimentais/parasitologia , Neoplasias Experimentais/urina , Opistorquíase/patologia , Oxisteróis/sangue , Oxisteróis/urina
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