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1.

Efficacy of DYRK1A inhibitors in novel models of Down syndrome acute lymphoblastic leukemia.

Carey-Smith, Shannon L; Simad, Maryam H; Panchal, Kunjal; Aya-Bonilla, Carlos; Smolders, Hannah; Lin, Sang; Armitage, Jesse D; Nguyen, Vivien T; Bentley, Kathryn; Ford, Jette; Singh, Sajla; Oommen, Joyce; Laurent, Anouchka P; Mercher, Thomas; Crispino, John D; Montgomery, Andrew P; Kassiou, Michael; Besson, Thierry; Deau, Emmanuel; Meijer, Laurent; Cheung, Laurence C; Kotecha, Rishi S; Malinge, Sébastien.

Haematologica ; 2024 Feb 29.

Artigo em Inglês | MEDLINE | ID: mdl-38426275

2.

Down syndrome and leukemia: from basic mechanisms to clinical advances.

Baruchel, André; Bourquin, Jean-Pierre; Crispino, John; Cuartero, Sergi; Hasle, Henrik; Hitzler, Johann; Klusmann, Jan-Henning; Izraeli, Shai; Lane, Andrew A; Malinge, Sébastien; Rabin, Karen R; Roberts, Irene; Ryeom, Sandra; Tasian, Sarah K; Wagenblast, Elvin.

Haematologica ; 108(10): 2570-2581, 2023 10 01.

Artigo em Inglês | MEDLINE | ID: mdl-37439336

3.

Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers.

Fagnan, Alexandre; Bagger, Frederik Otzen; Piqué-Borràs, Maria-Riera; Ignacimouttou, Cathy; Caulier, Alexis; Lopez, Cécile K; Robert, Elie; Uzan, Benjamin; Gelsi-Boyer, Véronique; Aid, Zakia; Thirant, Cécile; Moll, Ute; Tauchmann, Samantha; Kurtovic-Kozaric, Amina; Maciejewski, Jaroslaw; Dierks, Christine; Spinelli, Orietta; Salmoiraghi, Silvia; Pabst, Thomas; Shimoda, Kazuya; Deleuze, Virginie; Lapillonne, Hélène; Sweeney, Connor; De Mas, Véronique; Leite, Betty; Kadri, Zahra; Malinge, Sébastien; de Botton, Stéphane; Micol, Jean-Baptiste; Kile, Benjamin; Carmichael, Catherine L; Iacobucci, Ilaria; Mullighan, Charles G; Carroll, Martin; Valent, Peter; Bernard, Olivier A; Delabesse, Eric; Vyas, Paresh; Birnbaum, Daniel; Anguita, Eduardo; Garçon, Loïc; Soler, Eric; Schwaller, Juerg; Mercher, Thomas.

Blood ; 136(6): 698-714, 2020 08 06.

Artigo em Inglês | MEDLINE | ID: mdl-32350520

4.

It is more "unbalanced" than you think.

Malinge, Sébastien.

Blood ; 141(10): 1095-1096, 2023 03 09.

Artigo em Inglês | MEDLINE | ID: mdl-36893009

5.

SNAIL trail in myeloid malignancies.

Malinge, Sébastien.

Blood ; 136(8): 920-921, 2020 08 20.

Artigo em Inglês | MEDLINE | ID: mdl-32818247

6.

Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling.

Malinge, Sébastien; Thiollier, Clarisse; Chlon, Timothy M; Doré, Louis C; Diebold, Lauren; Bluteau, Olivier; Mabialah, Vinciane; Vainchenker, William; Dessen, Philippe; Winandy, Susan; Mercher, Thomas; Crispino, John D.

Blood ; 121(13): 2440-51, 2013 Mar 28.

Artigo em Inglês | MEDLINE | ID: mdl-23335373

7.

Development of acute megakaryoblastic leukemia in Down syndrome is associated with sequential epigenetic changes.

Malinge, Sébastien; Chlon, Tim; Doré, Louis C; Ketterling, Rhett P; Tallman, Martin S; Paietta, Elisabeth; Gamis, Alan S; Taub, Jeffrey W; Chou, Stella T; Weiss, Mitchell J; Crispino, John D; Figueroa, Maria E.

Blood ; 122(14): e33-43, 2013 Oct 03.

Artigo em Inglês | MEDLINE | ID: mdl-23980066

8.

Romidepsin enhances the efficacy of cytarabine in vivo, revealing histone deacetylase inhibition as a promising therapeutic strategy for KMT2A-rearranged infant acute lymphoblastic leukemia.

Cheung, Laurence C; Cruickshank, Mark N; Hughes, Anastasia M; Singh, Sajla; Chua, Grace-Alyssa; Ford, Jette; Ferrari, Emanuela; Oommen, Joyce; Malinge, Sébastien; Lock, Richard B; Kees, Ursula R; Kotecha, Rishi S.

Haematologica ; 104(7): e300-e303, 2019 07.

Artigo em Inglês | MEDLINE | ID: mdl-30679330

9.

Characterization of mesenchymal stem cells in pre-B acute lymphoblastic leukemia.

Hughes, Anastasia M; Kuek, Vincent; Oommen, Joyce; Chua, Grace-Alyssa; van Loenhout, Maria; Malinge, Sebastien; Kotecha, Rishi S; Cheung, Laurence C.

Front Cell Dev Biol ; 11: 1005494, 2023.

Artigo em Inglês | MEDLINE | ID: mdl-36743421

10.

Preclinical efficacy of azacitidine and venetoclax for infant KMT2A-rearranged acute lymphoblastic leukemia reveals a new therapeutic strategy.

Cheung, Laurence C; Aya-Bonilla, Carlos; Cruickshank, Mark N; Chiu, Sung K; Kuek, Vincent; Anderson, Denise; Chua, Grace-Alyssa; Singh, Sajla; Oommen, Joyce; Ferrari, Emanuela; Hughes, Anastasia M; Ford, Jette; Kunold, Elena; Hesselman, Maria C; Post, Frederik; Faulk, Kelly E; Breese, Erin H; Guest, Erin M; Brown, Patrick A; Loh, Mignon L; Lock, Richard B; Kees, Ursula R; Jafari, Rozbeh; Malinge, Sébastien; Kotecha, Rishi S.

Leukemia ; 37(1): 61-71, 2023 01.

Artigo em Inglês | MEDLINE | ID: mdl-36380143

11.

A biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors.

Marques Da Costa, Maria Eugénia; Zaidi, Sakina; Scoazec, Jean-Yves; Droit, Robin; Lim, Wan Ching; Marchais, Antonin; Salmon, Jerome; Cherkaoui, Sarah; Morscher, Raphael J; Laurent, Anouchka; Malinge, Sébastien; Mercher, Thomas; Tabone-Eglinger, Séverine; Goddard, Isabelle; Pflumio, Francoise; Calvo, Julien; Redini, Francoise; Entz-Werlé, Natacha; Soriano, Aroa; Villanueva, Alberto; Cairo, Stefano; Chastagner, Pascal; Moro, Massimo; Owens, Cormac; Casanova, Michela; Hladun-Alvaro, Raquel; Berlanga, Pablo; Daudigeos-Dubus, Estelle; Dessen, Philippe; Zitvogel, Laurence; Lacroix, Ludovic; Pierron, Gaelle; Delattre, Olivier; Schleiermacher, Gudrun; Surdez, Didier; Geoerger, Birgit.

Commun Biol ; 6(1): 949, 2023 09 18.

Artigo em Inglês | MEDLINE | ID: mdl-37723198

12.

Stepwise GATA1 and SMC3 mutations alter megakaryocyte differentiation in a Down syndrome leukemia model.

Arkoun, Brahim; Robert, Elie; Boudia, Fabien; Mazzi, Stefania; Dufour, Virginie; Siret, Aurélie; Mammasse, Yasmine; Aid, Zakia; Vieira, Matthieu; Imanci, Aygun; Aglave, Marine; Cambot, Marie; Petermann, Rachel; Souquere, Sylvie; Rameau, Philippe; Catelain, Cyril; Diot, Romain; Tachdjian, Gérard; Hermine, Olivier; Droin, Nathalie; Debili, Najet; Plo, Isabelle; Malinge, Sébastien; Soler, Eric; Raslova, Hana; Mercher, Thomas; Vainchenker, William.

J Clin Invest ; 132(14)2022 07 15.

Artigo em Inglês | MEDLINE | ID: mdl-35587378

13.

Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome.

Malinge, Sébastien; Izraeli, Shai; Crispino, John D.

Blood ; 113(12): 2619-28, 2009 Mar 19.

Artigo em Inglês | MEDLINE | ID: mdl-19139078

14.

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies.

Abdel-Wahab, Omar; Mullally, Ann; Hedvat, Cyrus; Garcia-Manero, Guillermo; Patel, Jay; Wadleigh, Martha; Malinge, Sebastien; Yao, JinJuan; Kilpivaara, Outi; Bhat, Rukhmi; Huberman, Kety; Thomas, Sabrena; Dolgalev, Igor; Heguy, Adriana; Paietta, Elisabeth; Le Beau, Michelle M; Beran, Miloslav; Tallman, Martin S; Ebert, Benjamin L; Kantarjian, Hagop M; Stone, Richard M; Gilliland, D Gary; Crispino, John D; Levine, Ross L.

Blood ; 114(1): 144-7, 2009 Jul 02.

Artigo em Inglês | MEDLINE | ID: mdl-19420352

15.

Preclinical Evaluation of Carfilzomib for Infant KMT2A-Rearranged Acute Lymphoblastic Leukemia.

Cheung, Laurence C; de Kraa, Rebecca; Oommen, Joyce; Chua, Grace-Alyssa; Singh, Sajla; Hughes, Anastasia M; Ferrari, Emanuela; Ford, Jette; Chiu, Sung K; Stam, Ronald W; Kees, Ursula R; Malinge, Sébastien; Kotecha, Rishi S.

Front Oncol ; 11: 631594, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-33937032

16.

DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3.

Bhansali, Rahul S; Rammohan, Malini; Lee, Paul; Laurent, Anouchka P; Wen, Qiang; Suraneni, Praveen; Yip, Bon Ham; Tsai, Yi-Chien; Jenni, Silvia; Bornhauser, Beat; Siret, Aurélie; Fruit, Corinne; Pacheco-Benichou, Alexandra; Harris, Ethan; Besson, Thierry; Thompson, Benjamin J; Goo, Young Ah; Hijiya, Nobuko; Vilenchik, Maria; Izraeli, Shai; Bourquin, Jean-Pierre; Malinge, Sébastien; Crispino, John D.

J Clin Invest ; 131(1)2021 01 04.

Artigo em Inglês | MEDLINE | ID: mdl-33393494

17.

Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society.

Dierssen, Mara; Herault, Yann; Helguera, Pablo; Martínez de Lagran, Maria; Vazquez, Anna; Christian, Bradley; Carmona-Iragui, Maria; Wiseman, Frances; Mobley, William; Fisher, Elizabeth M C; Brault, Veronique; Esbensen, Anna; Jacola, Lisa M; Potier, Marie Claude; Hamlett, Eric D; Abbeduto, Leonard; Del Hoyo Soriano, Laura; Busciglio, Jorge; Iulita, Maria Florencia; Crispino, John; Malinge, Sébastien; Barone, Eugenio; Perluigi, Marzia; Costanzo, Floriana; Delabar, Jean Maurice; Bartesaghi, Renata; Dekker, Alain D; De Deyn, Peter; Fortea Ormaechea, Juan; Shaw, Patricia A; Haydar, Tarik F; Sherman, Stephanie L; Strydom, André; Bhattacharyya, Anita.

Mol Syndromol ; 12(4): 202-218, 2021 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-34421499

18.

Activating mutations in human acute megakaryoblastic leukemia.

Malinge, Sébastien; Ragu, Christine; Della-Valle, Veronique; Pisani, Didier; Constantinescu, Stefan N; Perez, Christelle; Villeval, Jean-Luc; Reinhardt, Dirk; Landman-Parker, Judith; Michaux, Lucienne; Dastugue, Nicole; Baruchel, André; Vainchenker, William; Bourquin, Jean-Pierre; Penard-Lacronique, Virginie; Bernard, Olivier A.

Blood ; 112(10): 4220-6, 2008 Nov 15.

Artigo em Inglês | MEDLINE | ID: mdl-18755984

19.

Gain of chromosome 21 in hematological malignancies: lessons from studying leukemia in children with Down syndrome.

Laurent, Anouchka P; Kotecha, Rishi S; Malinge, Sébastien.

Leukemia ; 34(8): 1984-1999, 2020 08.

Artigo em Inglês | MEDLINE | ID: mdl-32433508

20.

The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolution.

Anderson, Denise; Skut, Patrycja; Hughes, Anastasia M; Ferrari, Emanuela; Tickner, Jennifer; Xu, Jiake; Mullin, Benjamin H; Tang, Dave; Malinge, Sébastien; Kees, Ursula R; Kotecha, Rishi S; Lassmann, Timo; Cheung, Laurence C.

Sci Rep ; 10(1): 19173, 2020 11 05.

Artigo em Inglês | MEDLINE | ID: mdl-33154494

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