Detalhe da pesquisa
1.
Early investigation of a novel SI306 theranostic prodrug for glioblastoma treatment.
Drug Dev Res
; 85(1): e22158, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38349262
2.
Targeting GLI1 and GLI2 with small molecule inhibitors to suppress GLI-dependent transcription and tumor growth.
Pharmacol Res
; 195: 106858, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37473878
3.
Antiviral Activity of Cannabidiolic Acid and Its Methyl Ester against SARS-CoV-2.
J Nat Prod
; 86(7): 1698-1707, 2023 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37402317
4.
Effect of in vitro simulated digestion on the anti-Helicobacter Pylori activity of different Propolis extracts.
J Enzyme Inhib Med Chem
; 38(1): 2183810, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36916299
5.
Cannabidiol-rich non-psychotropic Cannabis sativa L. oils attenuate peripheral neuropathy symptoms by regulation of CB2-mediated microglial neuroinflammation.
Phytother Res
; 37(5): 1924-1937, 2023 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-36583304
6.
Helichrysum stoechas (L.) Moench reduces body weight gain and modulates mood disorders via inhibition of silent information regulator 1 (SIRT1) by arzanol.
Phytother Res
; 37(10): 4304-4320, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37433745
7.
Synthesis and biological activity evaluation of 3-(hetero) arylideneindolin-2-ones as potential c-Src inhibitors.
J Enzyme Inhib Med Chem
; 37(1): 2382-2394, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36050846
8.
Non-psychotropic Cannabis sativa L. phytocomplex modulates microglial inflammatory response through CB2 receptors-, endocannabinoids-, and NF-κB-mediated signaling.
Phytother Res
; 36(5): 2246-2263, 2022 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-35393641
9.
The Veterinary Anti-Parasitic Selamectin Is a Novel Inhibitor of the Mycobacterium tuberculosis DprE1 Enzyme.
Int J Mol Sci
; 23(2)2022 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35054958
10.
FFAR1/GPR40: One target, different binding sites, many agonists, no drugs, but a continuous and unprofitable tug-of-war between ligand lipophilicity, activity, and toxicity.
Bioorg Med Chem Lett
; 41: 127969, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33771587
11.
Pinocembrin and its linolenoyl ester derivative induce wound healing activity in HaCaT cell line potentially involving a GPR120/FFA4 mediated pathway.
Bioorg Chem
; 108: 104657, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33556697
12.
Pharmacophore-guided repurposing of fibrates and retinoids as GPR40 allosteric ligands with activity on insulin release.
J Enzyme Inhib Med Chem
; 36(1): 377-383, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-33525941
13.
The Antimalarial Mefloquine Shows Activity against Mycobacterium abscessus, Inhibiting Mycolic Acid Metabolism.
Int J Mol Sci
; 22(16)2021 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34445239
14.
Quercetin-3-oleoyl derivatives as new GPR40 agonists: Molecular docking studies and functional evaluation.
Bioorg Med Chem Lett
; 29(14): 1761-1764, 2019 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31104992
15.
Novel smoothened antagonists as anti-neoplastic agents for the treatment of osteosarcoma.
J Cell Physiol
; 233(6): 4961-4971, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29215700
16.
Smoothened-antagonists reverse homogentisic acid-induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria.
J Cell Physiol
; 232(11): 3103-3111, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28019670
17.
Homogentisate 1,2 dioxygenase is expressed in brain: implications in alkaptonuria.
J Inherit Metab Dis
; 38(5): 807-14, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25762405
18.
In Memory of Maurizio Botta: His Contribution to the Development of Computer-Aided Drug Design.
J Chem Inf Model
; 59(12): 4961-4967, 2019 12 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31804073
19.
Consensus screening for a challenging target: the quest for P-glycoprotein inhibitors.
RSC Med Chem
; 15(2): 720-732, 2024 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38389870
20.
Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened.
Mol Pharmacol
; 83(5): 1020-9, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23448715