1.
J Am Chem Soc
; 137(1): 90-3, 2015 Jan 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25548865
RESUMO
A highly efficient asymmetric hydrogenation of cyclic imines containing a pyridyl moiety was established by using iridium catalysts with chiral spiro phosphine-oxazoline ligands. This process will facilitate the development of new nicotine-related pharmaceuticals. The introduction of a substituent at the ortho position of the pyridyl ring to reduce its coordinating ability ensures the success of the hydrogenation and excellent enantioselectivity.