Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis.

Chu, Nam; Salguero, Antonieta L; Liu, Albert Z; Chen, Zan; Dempsey, Daniel R; Ficarro, Scott B; Alexander, William M; Marto, Jarrod A; Li, Yana; Amzel, L Mario; Gabelli, Sandra B; Cole, Philip A.

Cell ; 174(4): 897-907.e14, 2018 08 09.

Artigo em Inglês | MEDLINE | ID: mdl-30078705

2.

DUB to the rescue.

Teh, Wei Pin; Zhu, He; Marto, Jarrod A; Buhrlage, Sara J.

Mol Cell ; 82(8): 1411-1413, 2022 04 21.

Artigo em Inglês | MEDLINE | ID: mdl-35452613

3.

Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase.

Ji, Zhejian; Li, Hao; Peterle, Daniele; Paulo, Joao A; Ficarro, Scott B; Wales, Thomas E; Marto, Jarrod A; Gygi, Steven P; Engen, John R; Rapoport, Tom A.

Mol Cell ; 82(3): 570-584.e8, 2022 02 03.

Artigo em Inglês | MEDLINE | ID: mdl-34951965

4.

Epitope editing enables targeted immunotherapy of acute myeloid leukaemia.

Casirati, Gabriele; Cosentino, Andrea; Mucci, Adele; Salah Mahmoud, Mohammed; Ugarte Zabala, Iratxe; Zeng, Jing; Ficarro, Scott B; Klatt, Denise; Brendel, Christian; Rambaldi, Alessandro; Ritz, Jerome; Marto, Jarrod A; Pellin, Danilo; Bauer, Daniel E; Armstrong, Scott A; Genovese, Pietro.

Nature ; 621(7978): 404-414, 2023 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-37648862

5.

In vitro analysis of RNA polymerase II elongation complex dynamics.

Joo, Yoo Jin; Ficarro, Scott B; Chun, Yujin; Marto, Jarrod A; Buratowski, Stephen.

Genes Dev ; 33(9-10): 578-589, 2019 05 01.

Artigo em Inglês | MEDLINE | ID: mdl-30846429

6.

A small molecule exerts selective antiviral activity by targeting the human cytomegalovirus nuclear egress complex.

Chen, Han; Lye, Ming F; Gorgulla, Christoph; Ficarro, Scott B; Cuny, Gregory D; Scott, David A; Wu, Fan; Rothlauf, Paul W; Wang, Xiaoou; Fernandez, Rosio; Pesola, Jean M; Draga, Sorin; Marto, Jarrod A; Hogle, James M; Arthanari, Haribabu; Coen, Donald M.

PLoS Pathog ; 19(11): e1011781, 2023 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-37976321

7.

Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.

Park, Eunyoung; Rawson, Shaun; Li, Kunhua; Kim, Byeong-Won; Ficarro, Scott B; Pino, Gonzalo Gonzalez-Del; Sharif, Humayun; Marto, Jarrod A; Jeon, Hyesung; Eck, Michael J.

Nature ; 575(7783): 545-550, 2019 11.

Artigo em Inglês | MEDLINE | ID: mdl-31581174

8.

Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation.

Ferry, Laure; Fournier, Alexandra; Tsusaka, Takeshi; Adelmant, Guillaume; Shimazu, Tadahiro; Matano, Shohei; Kirsh, Olivier; Amouroux, Rachel; Dohmae, Naoshi; Suzuki, Takehiro; Filion, Guillaume J; Deng, Wen; de Dieuleveult, Maud; Fritsch, Lauriane; Kudithipudi, Srikanth; Jeltsch, Albert; Leonhardt, Heinrich; Hajkova, Petra; Marto, Jarrod A; Arita, Kyohei; Shinkai, Yoichi; Defossez, Pierre-Antoine.

Mol Cell ; 67(4): 550-565.e5, 2017 Aug 17.

Artigo em Inglês | MEDLINE | ID: mdl-28803780

9.

Downstream promoter interactions of TFIID TAFs facilitate transcription reinitiation.

Joo, Yoo Jin; Ficarro, Scott B; Soares, Luis M; Chun, Yujin; Marto, Jarrod A; Buratowski, Stephen.

Genes Dev ; 31(21): 2162-2174, 2017 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-29203645

10.

Direct Analysis of Phosphorylation Sites on the Rpb1 C-Terminal Domain of RNA Polymerase II.

Suh, Hyunsuk; Ficarro, Scott B; Kang, Un-Beom; Chun, Yujin; Marto, Jarrod A; Buratowski, Stephen.

Mol Cell ; 61(2): 297-304, 2016 Jan 21.

Artigo em Inglês | MEDLINE | ID: mdl-26799764

11.

Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo.

Dubiella, Christian; Pinch, Benika J; Koikawa, Kazuhiro; Zaidman, Daniel; Poon, Evon; Manz, Theresa D; Nabet, Behnam; He, Shuning; Resnick, Efrat; Rogel, Adi; Langer, Ellen M; Daniel, Colin J; Seo, Hyuk-Soo; Chen, Ying; Adelmant, Guillaume; Sharifzadeh, Shabnam; Ficarro, Scott B; Jamin, Yann; Martins da Costa, Barbara; Zimmerman, Mark W; Lian, Xiaolan; Kibe, Shin; Kozono, Shingo; Doctor, Zainab M; Browne, Christopher M; Yang, Annan; Stoler-Barak, Liat; Shah, Richa B; Vangos, Nicholas E; Geffken, Ezekiel A; Oren, Roni; Koide, Eriko; Sidi, Samuel; Shulman, Ziv; Wang, Chu; Marto, Jarrod A; Dhe-Paganon, Sirano; Look, Thomas; Zhou, Xiao Zhen; Lu, Kun Ping; Sears, Rosalie C; Chesler, Louis; Gray, Nathanael S; London, Nir.

Nat Chem Biol ; 17(9): 954-963, 2021 09.

Artigo em Inglês | MEDLINE | ID: mdl-33972797

12.

On-Chip Preconcentration Microchip Capillary Electrophoresis Based CE-PRM-LIVE for High-Throughput Selectivity Profiling of Deubiquitinase Inhibitors.

Zhu, He; Mellors, J Scott; Chan, Wai Cheung; Thompson, J Will; Ficarro, Scott B; Tavares, Isidoro; Bratt, Ariana S; Decker, Jens; Krause, Michael; Kruppa, Gary; Buhrlage, Sara J; Marto, Jarrod A.

Anal Chem ; 94(27): 9508-9513, 2022 07 12.

Artigo em Inglês | MEDLINE | ID: mdl-35729701

13.

Development of a covalent inhibitor of gut bacterial bile salt hydrolases.

Adhikari, Arijit A; Seegar, Tom C M; Ficarro, Scott B; McCurry, Megan D; Ramachandran, Deepti; Yao, Lina; Chaudhari, Snehal N; Ndousse-Fetter, Sula; Banks, Alexander S; Marto, Jarrod A; Blacklow, Stephen C; Devlin, A Sloan.

Nat Chem Biol ; 16(3): 318-326, 2020 03.

Artigo em Inglês | MEDLINE | ID: mdl-32042200

14.

Identification of a potent and selective covalent Pin1 inhibitor.

Pinch, Benika J; Doctor, Zainab M; Nabet, Behnam; Browne, Christopher M; Seo, Hyuk-Soo; Mohardt, Mikaela L; Kozono, Shingo; Lian, Xiaolan; Manz, Theresa D; Chun, Yujin; Kibe, Shin; Zaidman, Daniel; Daitchman, Dina; Yeoh, Zoe C; Vangos, Nicholas E; Geffken, Ezekiel A; Tan, Li; Ficarro, Scott B; London, Nir; Marto, Jarrod A; Buratowski, Stephen; Dhe-Paganon, Sirano; Zhou, Xiao Zhen; Lu, Kun Ping; Gray, Nathanael S.

Nat Chem Biol ; 16(9): 979-987, 2020 09.

Artigo em Inglês | MEDLINE | ID: mdl-32483379

15.

Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis.

Kim, Hyungjin; Dejsuphong, Donniphat; Adelmant, Guillaume; Ceccaldi, Raphael; Yang, Kailin; Marto, Jarrod A; D'Andrea, Alan D.

Mol Cell ; 54(1): 107-118, 2014 Apr 10.

Artigo em Inglês | MEDLINE | ID: mdl-24657165

16.

Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks.

Lee, Dong-Hyun; Acharya, Sanket S; Kwon, Mijung; Drane, Pascal; Guan, Yinghua; Adelmant, Guillaume; Kalev, Peter; Shah, Jagesh; Pellman, David; Marto, Jarrod A; Chowdhury, Dipanjan.

Mol Cell ; 54(3): 512-25, 2014 May 08.

Artigo em Inglês | MEDLINE | ID: mdl-24703952

17.

Chemoproteomic methods for covalent drug discovery.

Chan, Wai Cheung; Sharifzadeh, Shabnam; Buhrlage, Sara J; Marto, Jarrod A.

Chem Soc Rev ; 50(15): 8361-8381, 2021 Aug 02.

Artigo em Inglês | MEDLINE | ID: mdl-34143170

18.

Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.

Hill, Sarah J; Rolland, Thomas; Adelmant, Guillaume; Xia, Xianfang; Owen, Matthew S; Dricot, Amélie; Zack, Travis I; Sahni, Nidhi; Jacob, Yves; Hao, Tong; McKinney, Kristine M; Clark, Allison P; Reyon, Deepak; Tsai, Shengdar Q; Joung, J Keith; Beroukhim, Rameen; Marto, Jarrod A; Vidal, Marc; Gaudet, Suzanne; Hill, David E; Livingston, David M.

Genes Dev ; 28(17): 1957-75, 2014 Sep 01.

Artigo em Inglês | MEDLINE | ID: mdl-25184681

19.

PRM-LIVE with Trapped Ion Mobility Spectrometry and Its Application in Selectivity Profiling of Kinase Inhibitors.

Zhu, He; Ficarro, Scott B; Alexander, William M; Fleming, Laura E; Adelmant, Guillaume; Zhang, Tinghu; Willetts, Matthew; Decker, Jens; Brehmer, Sven; Krause, Michael; East, Michael P; Gray, Nathanael S; Johnson, Gary L; Kruppa, Gary; Marto, Jarrod A.

Anal Chem ; 93(41): 13791-13799, 2021 10 19.

Artigo em Inglês | MEDLINE | ID: mdl-34606255

20.

PQBP1, a factor linked to intellectual disability, affects alternative splicing associated with neurite outgrowth.

Wang, Qingqing; Moore, Michael J; Adelmant, Guillaume; Marto, Jarrod A; Silver, Pamela A.

Genes Dev ; 27(6): 615-26, 2013 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-23512658

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