Detalhe da pesquisa
1.
Azaindoles as Zinc-Binding Small-Molecule Inhibitors of the JAMM Protease CSN5.
Angew Chem Int Ed Engl
; 56(5): 1294-1297, 2017 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-27981705
2.
Human cytomegalovirus UL40 signal peptide regulates cell surface expression of the NK cell ligands HLA-E and gpUL18.
J Immunol
; 188(6): 2794-804, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22345649
3.
A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b.
Nat Cell Biol
; 8(8): 894-6, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16829951
4.
SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production.
Nat Cell Biol
; 8(8): 843-8, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16829952
5.
Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib.
J Med Chem
; 65(19): 13052-13073, 2022 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36178776
6.
Preclinical Characterization of a Next-Generation Brain Permeable, Paradox Breaker BRAF Inhibitor.
Clin Cancer Res
; 28(4): 770-780, 2022 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34782366
7.
Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides.
Trends Cell Biol
; 13(2): 71-8, 2003 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-12559757
8.
Cellular Resistance Mechanisms to Targeted Protein Degradation Converge Toward Impairment of the Engaged Ubiquitin Transfer Pathway.
ACS Chem Biol
; 14(10): 2215-2223, 2019 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31553577
9.
Drosophila signal peptide peptidase is an essential protease for larval development.
Genetics
; 170(1): 139-48, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15716490
10.
Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals.
Eur J Pharmacol
; 540(1-3): 10-7, 2006 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16697367
11.
Targeted inhibition of the COP9 signalosome for treatment of cancer.
Nat Commun
; 7: 13166, 2016 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-27774986
12.
A misassembled transmembrane domain of a polytopic protein associates with signal peptide peptidase.
Biochem J
; 384(Pt 1): 9-17, 2004 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15373738
13.
On the mechanism of SPP-catalysed intramembrane proteolysis; conformational control of peptide bond hydrolysis in the plane of the membrane.
FEBS Lett
; 564(3): 213-8, 2004 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-15111098
14.
The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain.
J Exp Med
; 210(1): 23-30, 2013 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23267013
15.
The signal peptide of the mouse mammary tumor virus Rem protein is released from the endoplasmic reticulum membrane and accumulates in nucleoli.
J Biol Chem
; 283(15): 9966-76, 2008 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-18270201
16.
Aspartic proteases in drug discovery.
Curr Pharm Des
; 13(3): 271-85, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17313361
17.
A sensitive fluorescence intensity assay for deubiquitinating proteases using ubiquitin-rhodamine110-glycine as substrate.
Anal Biochem
; 371(2): 201-7, 2007 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17869210
18.
Core protein of pestiviruses is processed at the C terminus by signal peptide peptidase.
J Virol
; 80(4): 1915-21, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16439547
19.
Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs.
Hum Mol Genet
; 12 Spec No 2: R201-6, 2003 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12966028
20.
Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis.
Mol Cell
; 10(4): 735-44, 2002 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-12419218