Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Widespread hydroxylation of unstructured lysine-rich protein domains by JMJD6.

Cockman, Matthew E; Sugimoto, Yoichiro; Pegg, Hamish B; Masson, Norma; Salah, Eidarus; Tumber, Anthony; Flynn, Helen R; Kirkpatrick, Joanna M; Schofield, Christopher J; Ratcliffe, Peter J.

Proc Natl Acad Sci U S A ; 119(32): e2201483119, 2022 08 09.

Artigo em Inglês | MEDLINE | ID: mdl-35930668

2.

Inherent DNA-binding specificities of the HIF-1α and HIF-2α transcription factors in chromatin.

Smythies, James A; Sun, Min; Masson, Norma; Salama, Rafik; Simpson, Peter D; Murray, Elizabeth; Neumann, Viviana; Cockman, Matthew E; Choudhry, Hani; Ratcliffe, Peter J; Mole, David R.

EMBO Rep ; 20(1)2019 01.

Artigo em Inglês | MEDLINE | ID: mdl-30429208

3.

The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia.

Tiana, Maria; Acosta-Iborra, Barbara; Puente-Santamaría, Laura; Hernansanz-Agustin, Pablo; Worsley-Hunt, Rebecca; Masson, Norma; García-Rio, Francisco; Mole, David; Ratcliffe, Peter; Wasserman, Wyeth W; Jimenez, Benilde; Del Peso, Luis.

Nucleic Acids Res ; 46(1): 120-133, 2018 01 09.

Artigo em Inglês | MEDLINE | ID: mdl-29059365

4.

Striking Oxygen Sensitivity of the Peptidylglycine α-Amidating Monooxygenase (PAM) in Neuroendocrine Cells.

Simpson, Peter D; Eipper, Betty A; Katz, Maximiliano J; Gandara, Lautaro; Wappner, Pablo; Fischer, Roman; Hodson, Emma J; Ratcliffe, Peter J; Masson, Norma.

J Biol Chem ; 290(41): 24891-901, 2015 Oct 09.

Artigo em Inglês | MEDLINE | ID: mdl-26296884

5.

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity.

Masson, Norma; Singleton, Rachelle S; Sekirnik, Rok; Trudgian, David C; Ambrose, Lucy J; Miranda, Melroy X; Tian, Ya-Min; Kessler, Benedikt M; Schofield, Christopher J; Ratcliffe, Peter J.

EMBO Rep ; 13(3): 251-7, 2012 Mar 01.

Artigo em Inglês | MEDLINE | ID: mdl-22310300

6.

Oncogenic Cell Tagging and Single-Cell Transcriptomics Reveal Cell Type-Specific and Time-Resolved Responses to Vhl Inactivation in the Kidney.

Kurlekar, Samvid; Lima, Joanna D C C; Li, Ran; Lombardi, Olivia; Masson, Norma; Barros, Ayslan B; Pontecorvi, Virginia; Mole, David R; Pugh, Christopher W; Adam, Julie; Ratcliffe, Peter J.

Cancer Res ; 84(11): 1799-1816, 2024 Jun 04.

Artigo em Inglês | MEDLINE | ID: mdl-38502859

7.

Two antioxidants are better than one.

Lappin, Terence; Masson, Norma.

Blood ; 117(20): 5276-7, 2011 May 19.

Artigo em Inglês | MEDLINE | ID: mdl-21596862

8.

Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants.

Masson, Norma; Keeley, Thomas P; Giuntoli, Beatrice; White, Mark D; Puerta, Mikel Lavilla; Perata, Pierdomenico; Hopkinson, Richard J; Flashman, Emily; Licausi, Francesco; Ratcliffe, Peter J.

Science ; 365(6448): 65-69, 2019 07 05.

Artigo em Inglês | MEDLINE | ID: mdl-31273118

9.

The Activity of JmjC Histone Lysine Demethylase KDM4A is Highly Sensitive to Oxygen Concentrations.

Hancock, Rebecca L; Masson, Norma; Dunne, Kate; Flashman, Emily; Kawamura, Akane.

ACS Chem Biol ; 12(4): 1011-1019, 2017 04 21.

Artigo em Inglês | MEDLINE | ID: mdl-28051298

10.

Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer.

Salama, Rafik; Masson, Norma; Simpson, Peter; Sciesielski, Lina Katrin; Sun, Min; Tian, Ya-Min; Ratcliffe, Peter John; Mole, David Robert.

PLoS One ; 10(8): e0134645, 2015.

Artigo em Inglês | MEDLINE | ID: mdl-26262842

11.

The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin.

Masson, Norma; Appelhoff, Rebecca J; Tuckerman, Jason R; Tian, Ya-Min; Demol, Hans; Puype, Magda; Vandekerckhove, Joel; Ratcliffe, Peter J; Pugh, Christopher W.

FEBS Lett ; 570(1-3): 166-70, 2004 Jul 16.

Artigo em Inglês | MEDLINE | ID: mdl-15251459

12.

Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways.

Masson, Norma; Ratcliffe, Peter J.

Cancer Metab ; 2(1): 3, 2014 Feb 04.

Artigo em Inglês | MEDLINE | ID: mdl-24491179

13.

Analysis of von Hippel-Lindau tumor suppressor as a mediator of cellular oxygen sensing.

Masson, Norma; Ratcliffe, Peter J.

Methods Enzymol ; 381: 305-20, 2004.

Artigo em Inglês | MEDLINE | ID: mdl-15063683

14.

Interaction of hydroxylated collagen IV with the von hippel-lindau tumor suppressor.

Grosfeld, Alexandra; Stolze, Ineke P; Cockman, Matthew E; Pugh, Christopher W; Edelmann, Mariola; Kessler, Benedikt; Bullock, Alex N; Ratcliffe, Peter J; Masson, Norma.

J Biol Chem ; 282(18): 13264-9, 2007 May 04.

Artigo em Inglês | MEDLINE | ID: mdl-17339318

15.

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).

Cockman, Matthew E; Lancaster, David E; Stolze, Ineke P; Hewitson, Kirsty S; McDonough, Michael A; Coleman, Mathew L; Coles, Charlotte H; Yu, Xiaohong; Hay, Ronald T; Ley, Steven C; Pugh, Christopher W; Oldham, Neil J; Masson, Norma; Schofield, Christopher J; Ratcliffe, Peter J.

Proc Natl Acad Sci U S A ; 103(40): 14767-72, 2006 Oct 03.

Artigo em Inglês | MEDLINE | ID: mdl-17003112

16.

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.

Masson, Norma; Ratcliffe, Peter J.

J Cell Sci ; 116(Pt 15): 3041-9, 2003 Aug 01.

Artigo em Inglês | MEDLINE | ID: mdl-12829734

17.

Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis.

Willam, Carsten; Masson, Norma; Tian, Ya-Min; Mahmood, S Aleema; Wilson, Michael I; Bicknell, Roy; Eckardt, Kai-Uwe; Maxwell, Patrick H; Ratcliffe, Peter J; Pugh, Christopher W.

Proc Natl Acad Sci U S A ; 99(16): 10423-8, 2002 Aug 06.

Artigo em Inglês | MEDLINE | ID: mdl-12149454

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Widespread hydroxylation of unstructured lysine-rich protein domains by JMJD6.

Inherent DNA-binding specificities of the HIF-1α and HIF-2α transcription factors in chromatin.

The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia.

Striking Oxygen Sensitivity of the Peptidylglycine α-Amidating Monooxygenase (PAM) in Neuroendocrine Cells.

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity.

Oncogenic Cell Tagging and Single-Cell Transcriptomics Reveal Cell Type-Specific and Time-Resolved Responses to Vhl Inactivation in the Kidney.

Two antioxidants are better than one.

Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants.

The Activity of JmjC Histone Lysine Demethylase KDM4A is Highly Sensitive to Oxygen Concentrations.

Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer.

The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin.

Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways.

Analysis of von Hippel-Lindau tumor suppressor as a mediator of cellular oxygen sensing.

Interaction of hydroxylated collagen IV with the von hippel-lindau tumor suppressor.

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.

Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis.