Detalhe da pesquisa
1.
Exposure-response relationships for the efficacy and safety of filgotinib and its metabolite GS-829845 in subjects with rheumatoid arthritis based on phase 2 and phase 3 studies.
Br J Clin Pharmacol
; 88(7): 3211-3221, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35072287
2.
Emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV pre-exposure prophylaxis (DISCOVER): primary results from a randomised, double-blind, multicentre, active-controlled, phase 3, non-inferiority trial.
Lancet
; 396(10246): 239-254, 2020 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32711800
3.
Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach.
Drug Metab Dispos
; 49(2): 159-168, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33051248
4.
Validation of LC-MS/MS methods for determination of remdesivir and its metabolites GS-441524 and GS-704277 in acidified human plasma and their application in COVID-19 related clinical studies.
Anal Biochem
; 617: 114118, 2021 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33508271
5.
Phase 1b study to investigate the safety and tolerability of idelalisib in Japanese patients with relapsed/refractory follicular lymphoma and chronic lymphocytic leukemia.
Jpn J Clin Oncol
; 50(12): 1395-1402, 2020 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32856068
6.
A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation.
Drug Metab Dispos
; 47(4): 350-357, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30622164
7.
Drug-Drug Interaction Studies Between Hepatitis C Virus Antivirals Sofosbuvir/Velpatasvir and Boosted and Unboosted Human Immunodeficiency Virus Antiretroviral Regimens in Healthy Volunteers.
Clin Infect Dis
; 67(6): 934-940, 2018 08 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-29522076
8.
Sofosbuvir and Ribavirin Liver Pharmacokinetics in Patients Infected with Hepatitis C Virus.
Antimicrob Agents Chemother
; 62(5)2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29439971
9.
The Drug-Drug Interaction Potential of Antiviral Agents for the Treatment of Chronic Hepatitis C Infection.
Drug Metab Dispos
; 46(8): 1212-1225, 2018 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-29695614
10.
Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics.
Drug Metab Dispos
; 46(2): 189-196, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29138286
11.
Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study.
Drug Metab Dispos
; 46(7): 943-952, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29695616
12.
Preclinical Pharmacokinetics and First-in-Human Pharmacokinetics, Safety, and Tolerability of Velpatasvir, a Pangenotypic Hepatitis C Virus NS5A Inhibitor, in Healthy Subjects.
Antimicrob Agents Chemother
; 61(5)2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28193657
13.
Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics.
Drug Metab Dispos
; 44(11): 1752-1758, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27543206
14.
A phase 3b study of sofosbuvir plus ribavirin in Taiwanese patients with chronic genotype 2 hepatitis C virus infection.
Liver Int
; 36(8): 1101-7, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26835876
15.
A phase 1, randomized, placebo-controlled, 3-day, dose-ranging study of GS-5885, an NS5A inhibitor, in patients with genotype 1 hepatitis C.
J Hepatol
; 57(1): 24-31, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22314425
16.
Physiologically-Based Pharmacokinetic Modeling of Remdesivir and Its Metabolites to Support Dose Selection for the Treatment of Pediatric Patients With COVID-19.
Clin Pharmacol Ther
; 109(4): 1116-1124, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33501997
17.
Lack of Drug-Drug Interaction Between Filgotinib, a Selective JAK1 Inhibitor, and Oral Hormonal Contraceptives Levonorgestrel/Ethinyl Estradiol in Healthy Volunteers.
Clin Pharmacol Drug Dev
; 10(4): 376-383, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32989920
18.
Pharmacokinetic, Pharmacodynamic, and Drug-Interaction Profile of Remdesivir, a SARS-CoV-2 Replication Inhibitor.
Clin Pharmacokinet
; 60(5): 569-583, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33782830
19.
Organic Anion Transporting Polypeptide Inhibition Dramatically Increases Plasma Exposure but not Pharmacodynamic Effect nor Inferred Hepatic Intracellular Exposure of Firsocostat.
Clin Pharmacol Ther
; 109(5): 1334-1341, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33141923
20.
Pharmacokinetics, Safety, and Tolerability of Selonsertib, an Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitor, Following First-in-Human Single and Multiple Ascending Doses in Healthy Subjects.
Clin Pharmacokinet
; 59(9): 1109-1117, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32333325