Detalhe da pesquisa
1.
HAP40 is a conserved central regulator of Huntingtin and a potential modulator of Huntington's disease pathogenesis.
PLoS Genet
; 18(7): e1010302, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35853002
2.
Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington's Disease.
J Med Chem
; 66(18): 13205-13246, 2023 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37712656
3.
Development of mAb-based polyglutamine-dependent and polyglutamine length-independent huntingtin quantification assays with cross-site validation.
PLoS One
; 17(4): e0266812, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35395060
4.
Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington's Disease Pathology.
J Med Chem
; 65(18): 12445-12459, 2022 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36098485
5.
Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington's Disease.
J Med Chem
; 65(14): 9819-9845, 2022 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35816678
6.
Evaluation of 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington's Disease.
ACS Med Chem Lett
; 12(3): 380-388, 2021 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33738065
7.
Structure-Based Exploration of Selectivity for ATM Inhibitors in Huntington's Disease.
J Med Chem
; 64(8): 5018-5036, 2021 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33783225
8.
Optimization of Potent and Selective Ataxia Telangiectasia-Mutated Inhibitors Suitable for a Proof-of-Concept Study in Huntington's Disease Models.
J Med Chem
; 62(6): 2988-3008, 2019 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30840447
9.
Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications.
Neuropsychopharmacology
; 33(3): 685-700, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17487225
10.
Identification of proteomic changes during differentiation of adult mouse subventricular zone progenitor cells.
Stem Cells Dev
; 16(1): 143-65, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17233554
11.
A rapid method for the quantification of mouse hippocampal neurogenesis in vivo by flow cytometry. Validation with conventional and enhanced immunohistochemical methods.
J Neurosci Methods
; 157(1): 54-63, 2006 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16876875
12.
Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class IIa Histone Deacetylase (HDAC) Inhibitors.
ACS Med Chem Lett
; 7(1): 34-9, 2016 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26819662
13.
Identification of signal transduction pathways used by orphan g protein-coupled receptors.
Assay Drug Dev Technol
; 1(2): 239-49, 2003 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15090189
14.
Native and recombinant human Edg4 receptor-mediated Ca(2+) signalling.
Assay Drug Dev Technol
; 1(1 Pt 1): 31-40, 2002 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-15090154
15.
Mechanisms of action of the antidepressants fluoxetine and the substance P antagonist L-000760735 are associated with altered neurofilaments and synaptic remodeling.
Brain Res
; 1002(1-2): 1-10, 2004 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-14988027
16.
Quantification assays for total and polyglutamine-expanded huntingtin proteins.
PLoS One
; 9(5): e96854, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24816435
17.
A monoclonal antibody TrkB receptor agonist as a potential therapeutic for Huntington's disease.
PLoS One
; 9(2): e87923, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24503862
18.
Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease.
J Med Chem
; 56(24): 9934-54, 2013 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24261862
19.
Oral administration of the pimelic diphenylamide HDAC inhibitor HDACi 4b is unsuitable for chronic inhibition of HDAC activity in the CNS in vivo.
PLoS One
; 7(9): e44498, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22973455
20.
Validation of a blood-based laboratory test to aid in the confirmation of a diagnosis of schizophrenia.
Biomark Insights
; 5: 39-47, 2010 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-20520744