Detalhe da pesquisa
1.
TMEM16A Potentiation: A Novel Therapeutic Approach for the Treatment of Cystic Fibrosis.
Am J Respir Crit Care Med
; 201(8): 946-954, 2020 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31898911
2.
Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors.
Bioorg Med Chem Lett
; 26(8): 2057-64, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26951753
3.
The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-acting ß2-adrenoceptor agonist.
Bioorg Med Chem Lett
; 24(17): 4341-7, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25065493
4.
ETD001: A novel inhaled ENaC blocker with an extended duration of action in vivo.
J Cyst Fibros
; 2024 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38851923
5.
Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway.
Bioorg Med Chem Lett
; 22(17): 5445-50, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22863202
6.
Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor.
J Med Chem
; 65(12): 8345-8379, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35500094
7.
Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors.
Bioorg Med Chem Lett
; 21(7): 1942-7, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21388807
8.
Design and synthesis of a library of chemokine antagonists.
Bioorg Med Chem Lett
; 21(21): 6249-52, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21940167
9.
Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application.
Bioorg Med Chem Lett
; 20(2): 603-7, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19963375
10.
A physical properties based approach for the exploration of a 4-hydroxybenzothiazolone series of beta2-adrenoceptor agonists as inhaled long-acting bronchodilators.
Bioorg Med Chem Lett
; 20(17): 5302-7, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20655218
11.
Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors.
Bioorg Med Chem Lett
; 20(8): 2609-13, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20231096
12.
An efficient synthesis of nitroalkenes by alkene cross metathesis: facile access to small ring systems.
Org Lett
; 9(14): 2613-6, 2007 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17550257
13.
Discovery and Optimization of 4-(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease (COPD).
J Med Chem
; 58(17): 6747-52, 2015 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26288344
14.
Adenosine receptor ligands as potential therapeutics in asthma.
Curr Opin Investig Drugs
; 3(1): 69-77, 2002 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-12054076
15.
Tropomyosin receptor kinase inhibitors: a patent update 2009 - 2013.
Expert Opin Ther Pat
; 24(7): 731-44, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24809946
16.
Solubility-driven optimization of phosphodiesterase-4 inhibitors leading to a clinical candidate.
J Med Chem
; 55(17): 7472-9, 2012 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22889281
17.
A drug resistance screen using a selective MET inhibitor reveals a spectrum of mutations that partially overlap with activating mutations found in cancer patients.
Cancer Res
; 71(15): 5255-64, 2011 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21697284
18.
A new orally bioavailable dual adenosine A2B/A3 receptor antagonist with therapeutic potential.
Bioorg Med Chem Lett
; 15(12): 3081-5, 2005 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15876531
19.
Structure based design of 4-(3-aminomethylphenyl)piperidinyl-1-amides: novel, potent, selective, and orally bioavailable inhibitors of betaII tryptase.
Bioorg Med Chem
; 13(8): 2859-72, 2005 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15781396
20.
Potent small molecule inhibitors of spleen tyrosine kinase (Syk).
Bioorg Med Chem Lett
; 13(18): 3111-4, 2003 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12941345