Detalhe da pesquisa
1.
Na/K-ATPase signaling tonically inhibits sodium reabsorption in the renal proximal tubule.
FASEB J
; 37(4): e22835, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36856735
2.
The sodium-glucose cotransporter isoform 1 (SGLT-1) is important for sperm energetics, motility, and fertility.
Biol Reprod
; 106(6): 1206-1217, 2022 06 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35420639
3.
Na,K-ATPase α4, and Not Na,K-ATPase α1, is the Main Contributor to Sperm Motility, But its High Ouabain Binding Affinity Site is Not Required for Male Fertility in Mice.
J Membr Biol
; 254(5-6): 549-561, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34129092
4.
Multi-Electrode Array of Sensory Neurons as an In Vitro Platform to Identify the Nociceptive Response to Pharmaceutical Buffer Systems of Injectable Biologics.
Pharm Res
; 38(7): 1179-1186, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-34244893
5.
Na,K-ATPase Atp1a4 isoform is important for maintaining sperm flagellar shape.
J Assist Reprod Genet
; 38(6): 1493-1505, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-33977467
6.
Stimulus intensity-dependent recruitment of NaV1 subunits in action potential initiation in nerve terminals of vagal C-fibers innervating the esophagus.
Am J Physiol Gastrointest Liver Physiol
; 319(4): G443-G453, 2020 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32726130
7.
Extracellular signal-regulated kinases mediate the enhancing effects of inflammatory mediators on resurgent currents in dorsal root ganglion neurons.
Mol Pain
; 15: 1744806919837104, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30803321
8.
Control of Neurotransmission by NaV1.7 in Human, Guinea Pig, and Mouse Airway Parasympathetic Nerves.
J Pharmacol Exp Ther
; 361(1): 172-180, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28138042
9.
The discovery of benzoxazine sulfonamide inhibitors of NaV1.7: Tools that bridge efficacy and target engagement.
Bioorg Med Chem Lett
; 27(15): 3477-3485, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28629594
10.
Tetrodotoxin-resistant sodium channels in sensory neurons generate slow resurgent currents that are enhanced by inflammatory mediators.
J Neurosci
; 34(21): 7190-7, 2014 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24849353
11.
The discovery of aminopyrazines as novel, potent Na(v)1.7 antagonists: hit-to-lead identification and SAR.
Bioorg Med Chem Lett
; 22(5): 2033-42, 2012 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22306122
12.
Discovery and hit-to-lead optimization of pyrrolopyrimidines as potent, state-dependent Na(v)1.7 antagonists.
Bioorg Med Chem Lett
; 22(5): 2052-62, 2012 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22318156
13.
Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists.
Bioorg Med Chem Lett
; 22(2): 1055-60, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22209205
14.
Antitussive effects of NaV 1.7 blockade in Guinea pigs.
Eur J Pharmacol
; 907: 174192, 2021 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34010618
15.
21-Benzylidene digoxin decreases proliferation by inhibiting the EGFR/ERK signaling pathway and induces apoptosis in HeLa cells.
Steroids
; 155: 108551, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31812624
16.
Synthesis and activity of substituted carbamates as potentiators of the alpha4beta2 nicotinic acetylcholine receptor.
Bioorg Med Chem Lett
; 18(20): 5643-7, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18805006
17.
Discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant alpha4beta2 nicotinic acetylcholine receptor potentiators.
Bioorg Med Chem Lett
; 18(19): 5209-12, 2008 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18789861
18.
The effects of plasma proteins on delayed repolarization in vitro with cisapride, risperidone, and D, L-sotalol.
J Pharmacol Toxicol Methods
; 56(1): 11-7, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17350293
19.
Targeting the Nerve Growth Factor (NGF) Pathway in Drug Discovery. Potential Applications to New Therapies for Chronic Pain.
J Med Chem
; 60(1): 66-88, 2017 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27779399
20.
Correction to "Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement".
ACS Med Chem Lett
; 8(3): 378, 2017 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28337335