Detalhe da pesquisa
1.
Structures of fungal and plant acetohydroxyacid synthases.
Nature
; 586(7828): 317-321, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32640464
2.
Inhibitors for metallo-ß-lactamases from the B1 and B3 subgroups provide an avenue to combat a major mechanism of antibiotic resistance.
Bioorg Med Chem Lett
; 92: 129387, 2023 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37369333
3.
Discovery of a Pyrimidinedione Derivative with Potent Inhibitory Activity against Mycobacterium tuberculosis Ketol-Acid Reductoisomerase.
Chemistry
; 27(9): 3130-3141, 2021 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33215746
4.
Discovery, Synthesis and Evaluation of a Ketol-Acid Reductoisomerase Inhibitor.
Chemistry
; 26(41): 8958-8968, 2020 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32198779
5.
Inhibition studies of ketol-acid reductoisomerases from pathogenic microorganisms.
Arch Biochem Biophys
; 692: 108516, 2020 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32745463
6.
Rapid discovery of a selective butyrylcholinesterase inhibitor using structure-based virtual screening.
Bioorg Med Chem Lett
; 30(24): 127609, 2020 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33039562
7.
Design, synthesis, biological evaluation and in silico studies of certain aryl sulfonyl hydrazones conjugated with 1,3-diaryl pyrazoles as potent metallo-ß-lactamase inhibitors.
Bioorg Chem
; 105: 104386, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33137556
8.
The Binding Mode of an ADP Analogue to a Metallohydrolase Mimics the Likely Transition State.
Chembiochem
; 20(12): 1536-1540, 2019 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30719821
9.
Visualization of the Reaction Trajectory and Transition State in a Hydrolytic Reaction Catalyzed by a Metalloenzyme.
Chemistry
; 23(20): 4778-4781, 2017 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28261912
10.
Crystal Structures of Staphylococcus aureus Ketol-Acid Reductoisomerase in Complex with Two Transition State Analogues that Have Biocidal Activity.
Chemistry
; 23(72): 18289-18295, 2017 Dec 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28975665
11.
Claisen rearrangements of benzyl vinyl ethers: theoretical investigation of mechanism, substituent effects, and regioselectivity.
Org Biomol Chem
; 15(37): 7887-7893, 2017 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28891574
12.
Diethylalkylsulfonamido(4-methoxyphenyl)methyl)phosphonate/phosphonic acid derivatives act as acid phosphatase inhibitors: synthesis accompanied by experimental and molecular modeling assessments.
J Enzyme Inhib Med Chem
; 32(1): 20-28, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27766897
13.
Captopril analogues as metallo-ß-lactamase inhibitors.
Bioorg Med Chem Lett
; 26(6): 1589-1593, 2016 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26883147
14.
'Click' assembly of glycoclusters and discovery of a trehalose analogue that retards Aß40 aggregation and inhibits Aß40-induced neurotoxicity.
Bioorg Med Chem Lett
; 24(18): 4523-4528, 2014 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25172417
15.
Binuclear metallohydrolases: complex mechanistic strategies for a simple chemical reaction.
Acc Chem Res
; 45(9): 1593-603, 2012 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22698580
16.
Identification and characterization of an unusual metallo-ß-lactamase from Serratia proteamaculans.
J Biol Inorg Chem
; 18(7): 855-63, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23982345
17.
Synthesis of a series of carbon-14 labeled tetrahydropyrido[4,3-d]pyrimidin-4(3H)-ones.
J Labelled Comp Radiopharm
; 56(14): 722-5, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24339011
18.
Cyclodextrin-crosslinked poly(acrylic acid): adhesion and controlled release of diflunisal and fluconazole from solid dosage forms.
AAPS PharmSciTech
; 14(1): 301-11, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23307066
19.
Optimization of an α-aminonaphthylmethylphosphonic acid inhibitor of purple acid phosphatase using rational structure-based design approaches.
Eur J Med Chem
; 254: 115383, 2023 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37087894
20.
Penicillin inhibitors of purple acid phosphatase.
Bioorg Med Chem Lett
; 22(7): 2555-9, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22366658