RESUMO
The occurrence of resistance to the streptogramin quinupristin-dalfopristin in Enterococcus faecium isolates from chickens on the Eastern Seaboard, was evaluated. Quinupristin-dalfopristin resistance was found in 51 to 78% of E. faecium isolates from the food production environment. The high level of resistance in this organism suggests that this reservoir of resistance may compromise the therapeutic potential of quinupristin-dalfopristin.
Assuntos
Criação de Animais Domésticos , Galinhas/microbiologia , Quimioterapia Combinada/farmacologia , Enterococcus faecium/efeitos dos fármacos , Microbiologia Ambiental , Virginiamicina/farmacologia , Animais , Resistência Microbiana a Medicamentos , Enterococcus faecium/isolamento & purificação , Infecções por Bactérias Gram-Positivas/microbiologiaRESUMO
The in vitro activities of LY333328 were compared with those of vancomycin, teicoplanin, and quinupristin-dalfopristin (Synercid) against 219 strains of enterococci and staphylococci, including vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus. MICs and MBCs were determined by a microtiter dilution protocol. LY333328 demonstrated superior activity against vancomycin-resistant enterococci and was the only antibiotic which was bactericidal. Its potency was comparable or superior to those of other antibiotics tested against methicillin-resistant staphylococci.