Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Redox State Controls Phase Separation of the Yeast Ataxin-2 Protein via Reversible Oxidation of Its Methionine-Rich Low-Complexity Domain.

Kato, Masato; Yang, Yu-San; Sutter, Benjamin M; Wang, Yun; McKnight, Steven L; Tu, Benjamin P.

Cell ; 177(3): 711-721.e8, 2019 04 18.

Artigo em Inglês | MEDLINE | ID: mdl-30982603

2.

A Solid-State Conceptualization of Information Transfer from Gene to Message to Protein.

Kato, Masato; McKnight, Steven L.

Annu Rev Biochem ; 87: 351-390, 2018 06 20.

Artigo em Inglês | MEDLINE | ID: mdl-29195049

3.

Structure of FUS Protein Fibrils and Its Relevance to Self-Assembly and Phase Separation of Low-Complexity Domains.

Murray, Dylan T; Kato, Masato; Lin, Yi; Thurber, Kent R; Hung, Ivan; McKnight, Steven L; Tycko, Robert.

Cell ; 171(3): 615-627.e16, 2017 Oct 19.

Artigo em Inglês | MEDLINE | ID: mdl-28942918

4.

Protein domains of low sequence complexity-dark matter of the proteome.

McKnight, Steven L.

Genes Dev ; 38(5-6): 205-212, 2024 Apr 17.

Artigo em Inglês | MEDLINE | ID: mdl-38503517

5.

Toxic PR Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers.

Lin, Yi; Mori, Eiichiro; Kato, Masato; Xiang, Siheng; Wu, Leeju; Kwon, Ilmin; McKnight, Steven L.

Cell ; 167(3): 789-802.e12, 2016 Oct 20.

Artigo em Inglês | MEDLINE | ID: mdl-27768897

6.

The LC Domain of hnRNPA2 Adopts Similar Conformations in Hydrogel Polymers, Liquid-like Droplets, and Nuclei.

Xiang, Siheng; Kato, Masato; Wu, Leeju C; Lin, Yi; Ding, Ming; Zhang, Yajie; Yu, Yonghao; McKnight, Steven L.

Cell ; 163(4): 829-39, 2015 Nov 05.

Artigo em Inglês | MEDLINE | ID: mdl-26544936

7.

P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage.

Wang, Gelin; Han, Ting; Nijhawan, Deepak; Theodoropoulos, Pano; Naidoo, Jacinth; Yadavalli, Sivaramakrishnan; Mirzaei, Hamid; Pieper, Andrew A; Ready, Joseph M; McKnight, Steven L.

Cell ; 158(6): 1324-1334, 2014 Sep 11.

Artigo em Inglês | MEDLINE | ID: mdl-25215490

8.

Acetate dependence of tumors.

Comerford, Sarah A; Huang, Zhiguang; Du, Xinlin; Wang, Yun; Cai, Ling; Witkiewicz, Agnes K; Walters, Holly; Tantawy, Mohammed N; Fu, Allie; Manning, H Charles; Horton, Jay D; Hammer, Robert E; McKnight, Steven L; Tu, Benjamin P.

Cell ; 159(7): 1591-602, 2014 Dec 18.

Artigo em Inglês | MEDLINE | ID: mdl-25525877

9.

Influence of metabolism on epigenetics and disease.

Kaelin, William G; McKnight, Steven L.

Cell ; 153(1): 56-69, 2013 Mar 28.

Artigo em Inglês | MEDLINE | ID: mdl-23540690

10.

Phosphorylation-regulated binding of RNA polymerase II to fibrous polymers of low-complexity domains.

Kwon, Ilmin; Kato, Masato; Xiang, Siheng; Wu, Leeju; Theodoropoulos, Pano; Mirzaei, Hamid; Han, Tina; Xie, Shanhai; Corden, Jeffry L; McKnight, Steven L.

Cell ; 155(5): 1049-1060, 2013 Nov 21.

Artigo em Inglês | MEDLINE | ID: mdl-24267890

11.

Pure genes, pure genius.

McKnight, Steven L.

Cell ; 150(6): 1100-2, 2012 Sep 14.

Artigo em Inglês | MEDLINE | ID: mdl-22980972

12.

Cell-free formation of RNA granules: bound RNAs identify features and components of cellular assemblies.

Han, Tina W; Kato, Masato; Xie, Shanhai; Wu, Leeju C; Mirzaei, Hamid; Pei, Jimin; Chen, Min; Xie, Yang; Allen, Jeffrey; Xiao, Guanghua; McKnight, Steven L.

Cell ; 149(4): 768-79, 2012 May 11.

Artigo em Inglês | MEDLINE | ID: mdl-22579282

13.

Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels.

Kato, Masato; Han, Tina W; Xie, Shanhai; Shi, Kevin; Du, Xinlin; Wu, Leeju C; Mirzaei, Hamid; Goldsmith, Elizabeth J; Longgood, Jamie; Pei, Jimin; Grishin, Nick V; Frantz, Douglas E; Schneider, Jay W; Chen, She; Li, Lin; Sawaya, Michael R; Eisenberg, David; Tycko, Robert; McKnight, Steven L.

Cell ; 149(4): 753-67, 2012 May 11.

Artigo em Inglês | MEDLINE | ID: mdl-22579281

14.

Oxidative regulation of TDP-43 self-association by a ß-to-α conformational switch.

Gu, Jinge; Zhou, Xiaoming; Sutherland, Lillian; Kato, Masato; Jaczynska, Klaudia; Rizo, Josep; McKnight, Steven L.

Proc Natl Acad Sci U S A ; 120(41): e2311416120, 2023 10 10.

Artigo em Inglês | MEDLINE | ID: mdl-37782781

15.

Discovery of a proneurogenic, neuroprotective chemical.

Pieper, Andrew A; Xie, Shanhai; Capota, Emanuela; Estill, Sandi Jo; Zhong, Jeannie; Long, Jeffrey M; Becker, Ginger L; Huntington, Paula; Goldman, Shauna E; Shen, Ching-Han; Capota, Maria; Britt, Jeremiah K; Kotti, Tiina; Ure, Kerstin; Brat, Daniel J; Williams, Noelle S; MacMillan, Karen S; Naidoo, Jacinth; Melito, Lisa; Hsieh, Jenny; De Brabander, Jef; Ready, Joseph M; McKnight, Steven L.

Cell ; 142(1): 39-51, 2010 Jul 09.

Artigo em Inglês | MEDLINE | ID: mdl-20603013

16.

How do protein domains of low sequence complexity work?

Kato, Masato; Zhou, Xiaoming; McKnight, Steven L.

RNA ; 28(1): 3-15, 2022 01.

Artigo em Inglês | MEDLINE | ID: mdl-34670847

17.

Unconventional wisdom.

McKnight, Steven L.

Cell ; 138(5): 817-9, 2009 Sep 04.

Artigo em Inglês | MEDLINE | ID: mdl-19737508

18.

The low-complexity domain of the FUS RNA binding protein self-assembles via the mutually exclusive use of two distinct cross-ß cores.

Kato, Masato; McKnight, Steven L.

Proc Natl Acad Sci U S A ; 118(42)2021 10 19.

Artigo em Inglês | MEDLINE | ID: mdl-34654750

19.

Transiently structured head domains control intermediate filament assembly.

Zhou, Xiaoming; Lin, Yi; Kato, Masato; Mori, Eiichiro; Liszczak, Glen; Sutherland, Lillian; Sysoev, Vasiliy O; Murray, Dylan T; Tycko, Robert; McKnight, Steven L.

Proc Natl Acad Sci U S A ; 118(8)2021 02 23.

Artigo em Inglês | MEDLINE | ID: mdl-33593918

20.

Passing Through.

McKnight, Steven L.

Trends Biochem Sci ; 44(11): 899-901, 2019 11.

Artigo em Inglês | MEDLINE | ID: mdl-31629612

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Redox State Controls Phase Separation of the Yeast Ataxin-2 Protein via Reversible Oxidation of Its Methionine-Rich Low-Complexity Domain.

A Solid-State Conceptualization of Information Transfer from Gene to Message to Protein.

Structure of FUS Protein Fibrils and Its Relevance to Self-Assembly and Phase Separation of Low-Complexity Domains.

Protein domains of low sequence complexity-dark matter of the proteome.

Toxic PR Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers.

The LC Domain of hnRNPA2 Adopts Similar Conformations in Hydrogel Polymers, Liquid-like Droplets, and Nuclei.

P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage.

Acetate dependence of tumors.

Influence of metabolism on epigenetics and disease.

Phosphorylation-regulated binding of RNA polymerase II to fibrous polymers of low-complexity domains.

Pure genes, pure genius.

Cell-free formation of RNA granules: bound RNAs identify features and components of cellular assemblies.

Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels.

Oxidative regulation of TDP-43 self-association by a ß-to-α conformational switch.

Discovery of a proneurogenic, neuroprotective chemical.

How do protein domains of low sequence complexity work?

Unconventional wisdom.

The low-complexity domain of the FUS RNA binding protein self-assembles via the mutually exclusive use of two distinct cross-ß cores.

Transiently structured head domains control intermediate filament assembly.

Passing Through.