Detalhe da pesquisa
1.
Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo.
J Pharmacol Exp Ther
; 341(2): 396-409, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22328573
2.
Biaryl piperidines as potent and selective delta opioid receptor ligands.
Bioorg Med Chem Lett
; 20(2): 503-7, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20015649
3.
Design and discovery of a selective small molecule κ opioid antagonist (2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine, PF-4455242).
J Med Chem
; 54(16): 5868-77, 2011 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21744827
4.
Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models.
J Med Chem
; 53(3): 1222-37, 2010 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20043678
5.
Preclinical pharmacology of the alpha4beta2 nAChR partial agonist varenicline related to effects on reward, mood and cognition.
Biochem Pharmacol
; 78(7): 813-24, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19501054