Detalhe da pesquisa
1.
Discovery of a benzimidazole-based dual FLT3/TrKA inhibitor targeting acute myeloid leukemia.
Bioorg Med Chem
; 56: 116596, 2022 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35033885
2.
Functional Characterization of the γ-Aminobutyric Acid Transporter from Mycobacterium smegmatis MC2 155 Reveals Sodium-Driven GABA Transport.
J Bacteriol
; 203(4)2021 01 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33288625
3.
Indolin-2-one derivatives as selective Aurora B kinase inhibitors targeting breast cancer.
Bioorg Chem
; 117: 105451, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34736137
4.
Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM.
Proc Natl Acad Sci U S A
; 115(8): 1795-1800, 2018 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-29434040
5.
The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target.
Bioorg Med Chem Lett
; 24(3): 911-6, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24398298
6.
An in silico structure-based approach to anti-infective drug discovery.
Parasitology
; 141(1): 17-27, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23768800
7.
Applications of structure-based design to antibacterial drug discovery.
Bioorg Chem
; 55: 69-76, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24962384
8.
From TgO/GABA-AT, GABA, and T-263 Mutant to Conception of Toxoplasma.
iScience
; 27(1): 108477, 2024 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38205261
9.
Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay.
Biochemistry
; 52(51): 9155-66, 2013 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-24295325
10.
Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides.
Bioorg Med Chem Lett
; 23(12): 3551-5, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23664871
11.
Developments in Non-Intercalating Bacterial Topoisomerase Inhibitors: Allosteric and ATPase Inhibitors of DNA Gyrase and Topoisomerase IV.
Pharmaceuticals (Basel)
; 16(2)2023 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37259406
12.
SAR investigation and optimization of benzimidazole-based derivatives as antimicrobial agents against Gram-negative bacteria.
Eur J Med Chem
; 247: 115040, 2023 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36584632
13.
Recent developments in the structural characterisation of the IR and IGF1R: implications for the design of IR-IGF1R hybrid receptor modulators.
RSC Med Chem
; 13(4): 360-374, 2022 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35647546
14.
De novo design of type II topoisomerase inhibitors as potential antimicrobial agents targeting a novel binding region.
RSC Med Chem
; 13(7): 831-839, 2022 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35919336
15.
Activity of and development of resistance to corallopyronin A, an inhibitor of RNA polymerase.
Antimicrob Agents Chemother
; 55(5): 2413-6, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21321139
16.
Is the ADP ribose site of the Chikungunya virus NSP3 Macro domain a target for antiviral approaches?
Acta Trop
; 207: 105490, 2020 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-32333884
17.
Author Correction: New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections.
Sci Rep
; 10(1): 5512, 2020 Mar 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32251362
18.
Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites.
Front Cell Infect Microbiol
; 10: 203, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32626661
19.
N-Cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites.
Eur J Med Chem
; 170: 141-156, 2019 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30878828
20.
Novel Synthetic Polyamines Have Potent Antimalarial Activities in vitro and in vivo by Decreasing Intracellular Spermidine and Spermine Concentrations.
Front Cell Infect Microbiol
; 9: 9, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30838177