RESUMO
Interventions addressing syndemics and ART adherence are needed for individuals with uncontrolled HIV and psychosocial problems. Twenty-seven participants with detectable HIV plasma viral load (PVL) or recent STI participated in an open trial of transdiagnostic adherence counseling and cognitive behavioral therapy. Outcomes were collected at baseline, 4-, and 8-months. Log PVL improved from baseline to 4-month (γ = - 1.13, 95% CI - 1.72, - 0.55, p < 0.001) and 8-month (γ = - 0.93, 95% CI - 1.57, - 0.30, p = 0.006), with more participants suppressed at 4- (χ2(1) = 9.09, p = 0.001) and 8-month (χ2(1) = 5.14, p = 0.016). Self-reported adherence improved across major assessments (γ = 0.87, 95% CI 0.28, 1.46, p = .005); Wisepill adherence did not. Negative affect declined during treatment (γ = - 0.28, 95% CI - 0.40, - 0.16, p < 0.001), with improvement at 4- (γ = - 4.34, 95% CI - 6.99, - 1.69, p = 0.002) but not 8-month. Positive affect trended positively during treatment and from baseline to 4-month, with significant 8-month improvement (γ = 3.84, 95% CI 0.33, 7.44, p = 0.04). Depressive symptoms did not change. In a complicated sample of participants selected for uncontrolled HIV, the intervention yielded improved PVL and self-reported adherence. Efforts to end HIV should improve upon strategies such as these, addressing syndemics. Registration: clinicaltrial.gov: NCT02696681.
Assuntos
Fármacos Anti-HIV/uso terapêutico , Coinfecção/epidemiologia , Infecções por HIV/tratamento farmacológico , Adesão à Medicação/psicologia , Autocuidado/métodos , Sindemia , Adulto , Feminino , Infecções por HIV/epidemiologia , Humanos , Masculino , Carga Viral , Adulto JovemRESUMO
We report the case of an 18-month-old boy who presented with caries in the upper central incisors associated with the use of propranolol solution for the treatment of an infantile hemangioma. This side effect of propranolol solution has not been reported before, and it may result from a sucrose-based excipient of the solution, or decreased salivation caused by beta-adrenergic antagonist effect of propranolol.
Assuntos
Cárie Dentária/induzido quimicamente , Hemangioma/tratamento farmacológico , Neoplasias Labiais/tratamento farmacológico , Propranolol/efeitos adversos , Sacarose/efeitos adversos , Administração Oral , Humanos , Lactente , Masculino , Soluções Farmacêuticas/administração & dosagem , Soluções Farmacêuticas/efeitos adversos , Propranolol/administração & dosagem , Sacarose/administração & dosagem , Vasodilatadores/administração & dosagem , Vasodilatadores/efeitos adversosRESUMO
Intestinal obstruction due to milk curds syndrome may present with a clinical picture and radiological findings which suggest the correct diagnosis. This type of intestinal obstruction usually affects neonates, previously healthy, with concentrated formula feeding. Surgical treatment may be avoided in some cases by the administration of Gastrografin enemas. Two patients with milk curd obstruction treatment in our Hospital, are presented.