Detalhe da pesquisa
1.
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.
Cell
; 156(4): 771-85, 2014 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24529379
2.
Bile acid analogues are activators of pyrin inflammasome.
J Biol Chem
; 294(10): 3359-3366, 2019 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30647128
3.
TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.
Mol Cell
; 47(4): 535-46, 2012 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-22795129
4.
Activation of a metabolic gene regulatory network downstream of mTOR complex 1.
Mol Cell
; 39(2): 171-83, 2010 Jul 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-20670887
5.
COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phase.
J Biol Chem
; 288(28): 20443-52, 2013 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-23689509
6.
Cell signalling: nutrient sensing lost in cancer.
Nature
; 498(7455): 444-5, 2013 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-23803840
7.
Perturbation of cullin deneddylation via conditional Csn8 ablation impairs the ubiquitin-proteasome system and causes cardiomyocyte necrosis and dilated cardiomyopathy in mice.
Circ Res
; 108(1): 40-50, 2011 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21051661
8.
Molecular targets and approaches to restore autophagy and lysosomal capacity in neurodegenerative disorders.
Mol Aspects Med
; 82: 101018, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34489092
9.
Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymes.
Mol Cell Biol
; 27(13): 4708-19, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17452440
10.
An iron-dependent metabolic vulnerability underlies VPS34-dependence in RKO cancer cells.
PLoS One
; 15(8): e0235551, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32833964
11.
Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.
Nat Cell Biol
; 21(5): 662-663, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30783264
12.
Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome.
BMC Biochem
; 9: 1, 2008 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-18173839
13.
The COP9 signalosome inhibits p27(kip1) degradation and impedes G1-S phase progression via deneddylation of SCF Cul1.
Curr Biol
; 12(8): 667-72, 2002 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-11967155
14.
Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death.
Mol Cell Biol
; 23(19): 6790-7, 2003 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-12972599
15.
Association of MTOR Mutations With Developmental Brain Disorders, Including Megalencephaly, Focal Cortical Dysplasia, and Pigmentary Mosaicism.
JAMA Neurol
; 73(7): 836-845, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27159400
16.
Purification of the COP9 signalosome from porcine spleen, human cell lines, and Arabidopsis thaliana plants.
Methods Enzymol
; 398: 468-81, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-16275351
17.
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
Nat Cell Biol
; 16(11): 1069-79, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25327288
18.
Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.
Nat Cell Biol
; 15(11): 1340-50, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24161930
19.
Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.
Sci Signal
; 5(217): ra24, 2012 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22457330
20.
CSN1 inhibits c-Jun phosphorylation and down-regulates ectopic expression of JNK1.
Protein Cell
; 2(5): 423-32, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21604193