Detalhe da pesquisa
1.
Structure-Based Design, Synthesis and Biological Evaluation of Bis-Tetrahydropyran Furan Acetogenin Mimics Targeting the Trypanosomatid F1 Component of ATP Synthase.
European J Org Chem
; 2019(31-32): 5434-5440, 2019 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31598093
2.
Direct and indirect approaches to identify drug modes of action.
IUBMB Life
; 70(1): 9-22, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29210173
3.
The trypanosome alternative oxidase: a potential drug target?
Parasitology
; 145(2): 175-183, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27894362
4.
Simplifying nature: Towards the design of broad spectrum kinetoplastid inhibitors, inspired by acetogenins.
Bioorg Med Chem
; 25(22): 6126-6136, 2017 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28185724
5.
African polyvalent antivenom can maintain pharmacological stability and ability to neutralise murine venom lethality for decades post-expiry: evidence for increasing antivenom shelf life to aid in alleviating chronic shortages.
BMJ Glob Health
; 9(3)2024 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38485142
6.
Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins.
Sci Transl Med
; 16(735): eadk1867, 2024 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38381847
7.
De novo designed proteins neutralize lethal snake venom toxins.
Res Sq
; 2024 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38798548
8.
Next-Generation Sequencing for Venomics: Application of Multi-Enzymatic Limited Digestion for Inventorying the Snake Venom Arsenal.
Toxins (Basel)
; 15(6)2023 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37368658
9.
ADDovenom: Thermostable Protein-Based ADDomer Nanoparticles as New Therapeutics for Snakebite Envenoming.
Toxins (Basel)
; 15(12)2023 11 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38133177
10.
Virus-like particles displaying conserved toxin epitopes stimulate polyspecific, murine antibody responses capable of snake venom recognition.
Sci Rep
; 12(1): 11328, 2022 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35790745
11.
Exploring the Utility of Recombinant Snake Venom Serine Protease Toxins as Immunogens for Generating Experimental Snakebite Antivenoms.
Toxins (Basel)
; 14(7)2022 06 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-35878181
12.
In vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typus.
Toxicon X
; 14: 100118, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-35321116
13.
Two snakebite antivenoms have potential to reduce Eswatini's dependency upon a single, increasingly unavailable product: Results of preclinical efficacy testing.
PLoS Negl Trop Dis
; 16(9): e0010496, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36108067
14.
Livestock herding and Fulani ethnicity are a combined risk factor for development of early adverse reactions to antivenom treatment: Findings from a cross-sectional study in Nigeria.
PLoS Negl Trop Dis
; 15(8): e0009518, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34383742
15.
An analysis of preclinical efficacy testing of antivenoms for sub-Saharan Africa: Inadequate independent scrutiny and poor-quality reporting are barriers to improving snakebite treatment and management.
PLoS Negl Trop Dis
; 14(8): e0008579, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32817682
16.
Design and Synthesis of Broad Spectrum Trypanosomatid Selective Inhibitors.
ACS Infect Dis
; 4(4): 560-567, 2018 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-29313667
17.
Photo-affinity labelling and biochemical analyses identify the target of trypanocidal simplified natural product analogues.
PLoS Negl Trop Dis
; 11(9): e0005886, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28873407
18.
Development of Simplified Heterocyclic Acetogenin Analogues as Potent and Selective Trypanosoma brucei Inhibitors.
ChemMedChem
; 11(14): 1503-6, 2016 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27283448
19.
Risk factors for soil-transmitted helminth infections during the first 3 years of life in the tropics; findings from a birth cohort.
PLoS Negl Trop Dis
; 8(2): e2718, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24587469
20.
Non-natural acetogenin analogues as potent Trypanosoma brucei inhibitors.
ChemMedChem
; 9(11): 2548-56, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25145275