RESUMO
In this study we have investigated the role of oral dimethylsulfoxide (DMSO) therapy in 2 patients with primary amyloidosis (AL) and in 2 patients with secondary amyloidosis (AA) to long-standing rheumatoid arthritis. DMSO treatment produced no beneficial effects in the patients with idiopathic amyloidosis. Instead the patients with secondary amyloidosis experienced a subjective improvement, a decrease of inflammatory activity of the rheumatoid arthritis and an unequivocal improvement of renal function following 3-6 months of DMSO therapy. No serious side effects of DMSO were observed except for unpleasant breath odour. We conclude that a treatment with oral DMSO may prolong life of patients with secondary amyloidosis.
Assuntos
Amiloidose/tratamento farmacológico , Dimetil Sulfóxido/uso terapêutico , Administração Oral , Idoso , Amiloidose/etiologia , Artrite Reumatoide/complicações , Artrite Reumatoide/tratamento farmacológico , Doença Crônica , Dimetil Sulfóxido/efeitos adversos , Avaliação de Medicamentos , Quimioterapia Combinada , Feminino , Halitose/induzido quimicamente , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
In the present study, the side effects of d-Penicillamine therapy in 54 patients with rheumatoid arthritis are analyzed. The therapeutic efficacy of the drug is emphasized; but in the meantime, the necessity is also stressed that the choice of this antirheumatic agent must imply the knowledge of the possible complications caused by its use and of the clinical features and laboratory data which would be useful for their early detection.