Dapsone-induced aplastic anemia in a woman with bullous systemic lupus erythematosus.

Aplastic anemia developed in a black woman who was receiving dapsone therapy for bullous systemic lupus erythematosus. Aplastic anemia is an uncommon adverse hematologic effect in patients treated with dapsone, the pathogenesis of which remains unknown. To our knowledge, dapsone-induced aplastic anemia has been previously reported in only four patients; the characteristics of their cases are described herein. Conservative monitoring of hematologic variables may alert clinicians to the early stages of this rare drug reaction.

Lingual hyperpigmentation associated with minocycline therapy.

Minocycline can cause hyperpigmentation of the conjunctiva, oral mucosa, and skin. Pigmentation of the oral mucosa may also be associated with a variety of endogenous or exogenous factors. Lingual pigmentation may be seen in Addison's disease, amalgam tatoo, malignant melanoma, Peutz-Jegher's syndrome, and other diseases. Two women who had isolated pigmentation of the tongue while taking minocycline are described; no other drug-induced pigmentation of their oral mucosa or skin occurred. Minocycline-induced pigmentation should be added to the differential diagnosis of isolated lingual hyperpigmentation.