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Sex Transm Infect ; 96(2): 106-109, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-31662418

RESUMO

OBJECTIVE: We aimed to characterise gonorrhoea transmission patterns in a diverse urban population by linking genomic, epidemiological and antimicrobial susceptibility data. METHODS: Neisseria gonorrhoeae isolates from patients attending sexual health clinics at Barts Health NHS Trust, London, UK, during an 11-month period underwent whole-genome sequencing and antimicrobial susceptibility testing. We combined laboratory and patient data to investigate the transmission network structure. RESULTS: One hundred and fifty-eight isolates from 158 patients were available with associated descriptive data. One hundred and twenty-nine (82%) patients identified as male and 25 (16%) as female; four (3%) records lacked gender information. Self-described ethnicities were: 51 (32%) English/Welsh/Scottish; 33 (21%) white, other; 23 (15%) black British/black African/black, other; 12 (8%) Caribbean; 9 (6%) South Asian; 6 (4%) mixed ethnicity; and 10 (6%) other; data were missing for 14 (9%). Self-reported sexual orientations were 82 (52%) men who have sex with men (MSM); 49 (31%) heterosexual; 2 (1%) bisexual; data were missing for 25 individuals. Twenty-two (14%) patients were HIV positive. Whole-genome sequence data were generated for 151 isolates, which linked 75 (50%) patients to at least one other case. Using sequencing data, we found no evidence of transmission networks related to specific ethnic groups (p=0.64) or of HIV serosorting (p=0.35). Of 82 MSM/bisexual patients with sequencing data, 45 (55%) belonged to clusters of ≥2 cases, compared with 16/44 (36%) heterosexuals with sequencing data (p=0.06). CONCLUSION: We demonstrate links between 50% of patients in transmission networks using a relatively small sample in a large cosmopolitan city. We found no evidence of HIV serosorting. Our results do not support assortative selectivity as an explanation for differences in gonorrhoea incidence between ethnic groups.


Assuntos
Gonorreia/epidemiologia , Infecções por HIV/epidemiologia , Neisseria gonorrhoeae/genética , Parceiros Sexuais , Antibacterianos/uso terapêutico , Povo Asiático , População Negra , Etnicidade , Feminino , Gonorreia/etnologia , Gonorreia/microbiologia , Gonorreia/transmissão , Seleção por Sorologia para HIV , Humanos , Londres/epidemiologia , Masculino , Testes de Sensibilidade Microbiana , Epidemiologia Molecular , Neisseria gonorrhoeae/fisiologia , Estudos Retrospectivos , Medicina Estatal , Reino Unido/epidemiologia , População Urbana , População Branca , Sequenciamento Completo do Genoma
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