1.
Angew Chem Int Ed Engl
; 53(38): 10077-81, 2014 Sep 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24975267
RESUMO
Cathepsinâ B (CtsB) is a lysosomal cysteine proteinase that is specifically translocated to the extracellular milieu during cancer progression. The development of a lipidated CtsB inhibitor incorporated into the envelope of a liposomal nanocarrier (LNC-NS-629) is described. Exâ vivo and inâ vivo studies confirmed selective targeting and internalization of LNC-NS-629 by tumor and stromal cells, thus validating CtsB targeting as a highly promising approach to cancer diagnosis and treatment.