RESUMO
BACKGROUND: Promoting Responsible Research and Innovation (RRI) is a major strategy of the "Science with and for Society" work program of the European Union's Horizon 2020 Framework Programme for Research and Innovation. RRI aims to achieve a better alignment of research and innovation with the values, needs, and expectations of society. The RRI strategy includes the "keys" of public engagement, open access, gender, ethics, and science education. The Structural Transformation to Attain Responsible BIOSciences (STARBIOS2) project promotes RRI in 6 European research institutions and universities from Bulgaria, Germany, Italy, Slovenia, Poland, and the United Kingdom, in partnership with a further 6 institutions from Brazil, Denmark, Italy, South Africa, Sweden, and the United States. OBJECTIVE: The project aims to attain RRI structural change in 6 European institutions by implementing action plans (APs) and developing APs for 3 non-European institutions active in the field of biosciences; use the implementation of APs as a learning process with a view to developing a set of guidelines on the implementation of RRI; and develop a sustainable model for RRI in biosciences. METHODS: The project comprises interrelated research and implementation designed to achieve the aforementioned specific objectives. The project is organized into 6 core work packages and 5 supporting work packages. The core work packages deal with the implementation of institutional APs in 6 European institutions based on the structural change activation model. The supporting work packages include technical assistance, learning process on RRI-oriented structural change, monitoring and assessment, communication and dissemination, and project management. RESULTS: The project is funded by Horizon 2020 and will run for 4 years (May 2016-April 2020). As of June 2018, the initial phase has been completed. The participating institutions have developed and approved APs and commenced their implementation. An observation tool has been launched by the Technical Assistance Team to collect information from the implementation of APs; the Evaluation & Assessment team has started monitoring the advancement of the project. As part of the communication and dissemination strategy, a project website, a Facebook page, and a Twitter account have been launched and are updated periodically. The International Scientific Advisory Committee has been formed to advise on the reporting and dissemination of the project's results. CONCLUSIONS: In the short term, we anticipate that the project will have a considerable impact on the organizational processes and structures, improving the RRI uptake in the participating institutions. In the medium term, we expect to make RRI-oriented organizational change scalable across Europe by developing guidelines on RRI implementation and an RRI model in biosciences. In the long term, we expect that the project would help increase the ability of research institutions to make discoveries and innovations in better alignment with societal needs and values. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/11745.
RESUMO
La rabdomiólisis se caracteriza por la destrucción de células musculares esqueléticas con liberacióndel contenido celular a la sangre. Sus causas son múltiples, y si bien una de las más frecuentes es el esfuerzo físicoextenuante, hay casos reportados tras practicar ejercicios de baja intensidad. Objetivo: reportar cuatro casos de rabdomiólisisinducida por ejercicio de baja intensidad. Pacientes y método: estudio descriptivo de una serie de cuatrocasos de rabdomiólisis inducida por ejercicio de baja intensidad, internados en un servicio de clínica médica entrelos años 2010 y 2012. Resultados: relación hombre/mujer 3/1, edad media 45.25 años (rango 29-58), media deduración de los síntomas hasta la consulta dos días (rango 1-3). El dolor fue el síntoma más relevante. Dos pacientespresentaron insuficiencia renal aguda con una media de duración de cuatro días (3-5). El tiempo medio hasta lanormalización de los valores de CPK fue de 8.75 días. La CPK media fue de 22.928,5 U/l (rango 1.415-65.672).Los cuatro pacientes recibieron hidratación parenteral vigorosa con solución salina y tuvieron buena evolución clínica.Conclusión: es importante considerar el diagnóstico de rabdomiólisis en pacientes que consultan por síntomasmusculares luego del ejercicio, incluso si éste fue de baja intensidad, pero ante la presencia de factores de riesgocomo hipokalemia, hidratación inadecuada, sudoración excesiva, temperatura ambiente y humedad elevadas. Elpronóstico de la rabdomiólisis es bueno cuando el cuadro es tratado en forma temprana.
Rhabdomyolysis is a syndrome characterised by the destruction of skeletal muscle, and release of cellular contentsinto the circulation. The causes vary; one of the most common causes is strenuous physical exercise, but there are reportsof the syndrome after practicing low-intensity exercises. Objective: to report four cases of low intensity exercise-inducedrhabdomyolysis. Patients and methods: descriptive study of a series of four cases with low intensity exercise-inducedrhabdomyolysis, admitted to the hospital between 2010 and 2012. Results: male/female ratio 3/1, mean age 45.25 years(range 29-58), mean duration of symptoms before consultation two days (range 1-3). The most important symptom waspain. Two patients presented with acute renal failure with a mean duration of four days (3-5). The average time untilthe normalization of CPK values was 8.75 days. The average CPK was 22,928.5 U/l (range 1,415-65,672). All patients creareceivedaggressive hydration with intravenous normal saline infusión, and had good clinical outcome. Conclusion: thediagnosis of rhabdomyolysis must be considered in patients who present with muscle symptoms after exercise, even if it wasof low intensity, especially in the presence of risk factors such as hypokalemia, inadequate hydration, excessive sweating, hotand humid weather. The prognosis of rhabdomyolysis is good when it is treated early.