Detalhe da pesquisa
1.
Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.
Cell
; 142(2): 270-83, 2010 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20655468
2.
Cell-autonomous effect of cardiomyocyte branched-chain amino acid catabolism in heart failure in mice.
Acta Pharmacol Sin
; 44(7): 1380-1390, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-36991098
3.
Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP.
Nature
; 494(7436): 256-60, 2013 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23292513
4.
Selective Activation of AMPK ß1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy.
J Pharmacol Exp Ther
; 361(2): 303-311, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28289077
5.
Glucagon: acute actions on hepatic metabolism.
Diabetologia
; 59(7): 1376-1381, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27115415
6.
Increased circulating progranulin is not sufficient to induce cardiac dysfunction or supraventricular arrhythmia.
Sci Rep
; 13(1): 21541, 2023 12 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38057339
7.
Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels.
Nat Commun
; 14(1): 4812, 2023 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37558654
8.
AMPK activation is sufficient to increase skeletal muscle glucose uptake and glycogen synthesis but is not required for contraction-mediated increases in glucose metabolism.
Heliyon
; 8(10): e11091, 2022 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-36303906
9.
BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice.
Mol Metab
; 66: 101611, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36220546
10.
Ligand-regulated peptide aptamers.
Methods Mol Biol
; 535: 315-31, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19377988
11.
Ligand-regulated peptide aptamers that inhibit the 5'-AMP-activated protein kinase.
J Mol Biol
; 365(4): 945-57, 2007 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-17116308
12.
Publisher Correction: Targeting hepatic glutaminase activity to ameliorate hyperglycemia.
Nat Med
; 24(9): 1482, 2018 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-29895835
13.
Targeting hepatic glutaminase activity to ameliorate hyperglycemia.
Nat Med
; 24(4): 518-524, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29578539
14.
Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models.
EBioMedicine
; 31: 122-132, 2018 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-29673898
15.
Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK).
J Med Chem
; 61(6): 2372-2383, 2018 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29466005
16.
Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.
Cell Metab
; 25(5): 1147-1159.e10, 2017 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28467931
17.
Ligand-regulated peptides: a general approach for modulating protein-peptide interactions with small molecules.
Chem Biol
; 12(7): 847-55, 2005 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16039531
18.
Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms.
Structure
; 22(8): 1161-1172, 2014 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25066137
19.
Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration.
Nat Med
; 18(6): 934-42, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22561686
20.
Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling.
J Clin Invest
; 121(6): 2518-28, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21606593