RESUMO
A prospective evaluation of ophthalmologic findings in 26 patients (25 men and one woman) with the acquired immune deficiency syndrome disclosed that 19 patients had significant ocular abnormalities. These included isolated retinal hemorrhages, cotton-wool spots, cytomegalovirus retinitis, acute retinal necrosis, cranial nerve palsies, and orbital Kaposi's sarcoma. Hemorrhages and cotton-wool spots appeared and disappeared spontaneously. Cytomegalovirus retinitis and acute retinal necrosis were progressive and destructive. The fundus findings did not correlate with the patient's general clinical status.
Assuntos
Síndrome da Imunodeficiência Adquirida/complicações , Oftalmopatias/etiologia , Adulto , Doenças dos Nervos Cranianos/etiologia , Infecções por Citomegalovirus/etiologia , Feminino , Humanos , Linfedema/etiologia , Masculino , Pessoa de Meia-Idade , Necrose , Pneumonia por Pneumocystis/etiologia , Estudos Prospectivos , Retina/patologia , Descolamento Retiniano/etiologia , Hemorragia Retiniana/etiologia , Retinite/etiologiaRESUMO
PURPOSE: To describe four patients who developed cystoid macular edema shortly after onset of treatment with latanoprost. METHOD: Retrospective review of medical records of patients with open-angle glaucoma who developed cystoid macular edema shortly after starting latanoprost. RESULTS: The use of topical latanoprost was temporally related to the development of cystoid macular edema in four patients (six eyes; two aphakic eyes and four pseudophakic eyes). Cystoid macular edema resolved in all patients after latanoprost was discontinued. CONCLUSIONS: Cystoid macular edema is a potential complication of latanoprost therapy. Further observations are needed to determine if the risk of cystoid macular edema is limited to or greatest in patients who are pseudophakic or aphakic.
Assuntos
Afacia Pós-Catarata/complicações , Edema Macular/induzido quimicamente , Prostaglandinas F Sintéticas/efeitos adversos , Pseudofacia/complicações , Idoso , Idoso de 80 Anos ou mais , Glaucoma de Ângulo Aberto/tratamento farmacológico , Humanos , Latanoprosta , Masculino , Soluções Oftálmicas , Estudos Retrospectivos , Acuidade VisualRESUMO
Tissue for pathologic examination was obtained from three cases of acute retinal necrosis syndrome. Virus particles belonging to the herpesvirus family were demonstrated in retinal biopsies from two patients, one of whom was immunosuppressed. Despite removal of large biopsy specimens, the retina has remained attached for 20 months postoperatively in one case and for three months in the other. In a third patient with acquired immune deficiency syndrome, the clinical course and postmortem immunopathology were suggestive of a herpes simplex virus infection, initially affecting the retina and subsequently the optic nerves, chiasm, tracts, and central nervous system. These cases illustrate that the virus associated with the acute retinal necrosis syndrome is easily demonstrable using vitrectomy and endoretinal biopsy in the acute phase of the disease, but may be difficult to demonstrate in chronically detached atrophic retinas.
Assuntos
Herpesviridae/isolamento & purificação , Doenças Retinianas/microbiologia , Doença Aguda , Adulto , Idoso , Biópsia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Necrose , Doenças Retinianas/patologia , SíndromeAssuntos
Síndrome da Imunodeficiência Adquirida/complicações , Oftalmopatias/etiologia , Síndrome da Imunodeficiência Adquirida/diagnóstico , Síndrome da Imunodeficiência Adquirida/etiologia , Adolescente , Adulto , Animais , Anticorpos Antivirais/análise , Linfócitos B/imunologia , Biópsia , Criança , Infecções por Citomegalovirus/diagnóstico , Infecções por Citomegalovirus/etiologia , Deltaretrovirus/imunologia , Deltaretrovirus/isolamento & purificação , Diagnóstico Diferencial , Modelos Animais de Doenças , Oftalmopatias/diagnóstico , Oftalmopatias/imunologia , Neoplasias Palpebrais/diagnóstico , Neoplasias Palpebrais/etiologia , Feminino , Humanos , Tolerância Imunológica , Linfonodos/patologia , Masculino , Pessoa de Meia-Idade , Prognóstico , Doenças Retinianas/diagnóstico , Doenças Retinianas/etiologia , Retinite/diagnóstico , Retinite/etiologia , Sarcoma de Kaposi/diagnóstico , Sarcoma de Kaposi/etiologiaRESUMO
Retinal detachment secondary to choroidal nevus may be caused by subretinal fluid accumulation or neovascularization. Foveal subretinal fluid or leakage of choroidal neovascularization may impair visual acuity. 10 cases of nevus with serous sensory retinal detachment successfully treated with laser photocoagulation are reviewed. 2 additional cases of successful laser therapy for retinal detachment secondary to choroidal neovascularization with nevus of the choroid are presented.