Detalhe da pesquisa
1.
Structural and Kinetic Characterization of a Novel N-acetylated Aliphatic Amine Metabolite of the PRMT Inhibitor, EPZ011652.
Drug Metab Dispos
; 43(7): 936-43, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25887455
2.
Studies Culminating in the Total Synthesis and Determination of the Absolute Configuration of (-)-Saudin.
Tetrahedron
; 67(51): 9787-9808, 2011 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22523435
3.
Thyroid receptor agonists for the treatment of androgenetic alopecia.
Bioorg Med Chem Lett
; 20(1): 306-8, 2010 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19900809
4.
Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production.
Bioorg Med Chem Lett
; 19(8): 2176-8, 2009 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19286380
5.
Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss.
Cancer Cell
; 36(1): 100-114.e25, 2019 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31257072
6.
Identification of a peptide inhibitor for the histone methyltransferase WHSC1.
PLoS One
; 13(5): e0197082, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29742153
7.
Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation.
PLoS One
; 13(6): e0197372, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29856759
8.
Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma.
Sci Rep
; 7(1): 17993, 2017 12 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-29269946
9.
4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution.
J Med Chem
; 49(16): 4896-911, 2006 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-16884302
10.
Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor.
ACS Med Chem Lett
; 7(2): 134-8, 2016 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26985287
11.
Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound.
ACS Med Chem Lett
; 6(6): 655-9, 2015 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26101569
12.
Rational design of a topical androgen receptor antagonist for the suppression of sebum production with properties suitable for follicular delivery.
J Med Chem
; 53(11): 4422-7, 2010 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-20462217
13.
A practical Buchwald-Hartwig amination of 2-bromopyridines with volatile amines.
J Org Chem
; 72(9): 3606-7, 2007 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-17417910
14.
An enantioselective total synthesis of (+)- and (-)-saudin. Determination of the absolute configuration.
J Am Chem Soc
; 124(2): 190-1, 2002 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-11782168