Detalhe da pesquisa
1.
Development of CVN424: A Selective and Novel GPR6 Inverse Agonist Effective in Models of Parkinson Disease.
J Pharmacol Exp Ther
; 377(3): 407-416, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33795395
2.
Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility.
Bioorg Med Chem
; 22(23): 6570-6585, 2014 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25456383
3.
Hydroxyethylamine-based inhibitors of BACE1: P1-P3 macrocyclization can improve potency, selectivity, and cell activity.
Bioorg Med Chem Lett
; 23(15): 4459-64, 2013 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23769639
4.
Structure guided P1' modifications of HEA derived ß-secretase inhibitors for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 22(11): 3607-11, 2012 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22572583
5.
First-Time Disclosure of CVN424, a Potent and Selective GPR6 Inverse Agonist for the Treatment of Parkinson's Disease: Discovery, Pharmacological Validation, and Identification of a Clinical Candidate.
J Med Chem
; 64(14): 9875-9890, 2021 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33861086
6.
Discovery of TAK-041: a Potent and Selective GPR139 Agonist Explored for the Treatment of Negative Symptoms Associated with Schizophrenia.
J Med Chem
; 64(15): 11527-11542, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34260228
7.
2-Aminothiadiazole inhibitors of AKT1 as potential cancer therapeutics.
Bioorg Med Chem Lett
; 20(5): 1652-6, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20137932
8.
Discovery of TRPM8 Antagonist ( S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine.
J Med Chem
; 61(18): 8186-8201, 2018 09 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30148953
9.
Functionalized Polymers-Emerging Versatile Tools for Solution-Phase Chemistry and Automated Parallel Synthesis.
Angew Chem Int Ed Engl
; 40(4): 650-679, 2001 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-11241594
10.
Optimization of potency and pharmacokinetic properties of tetrahydroisoquinoline transient receptor potential melastatin 8 (TRPM8) antagonists.
J Med Chem
; 57(7): 2989-3004, 2014 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24597733
11.
A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of ß-Secretase.
ACS Med Chem Lett
; 3(11): 886-91, 2012 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900403
12.
Design and preparation of a potent series of hydroxyethylamine containing ß-secretase inhibitors that demonstrate robust reduction of central ß-amyloid.
J Med Chem
; 55(21): 9009-24, 2012 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22468639
13.
Design and synthesis of potent, orally efficacious hydroxyethylamine derived ß-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.
J Med Chem
; 55(21): 9025-44, 2012 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22468684
14.
Studies towards the synthesis of azadirachtin: enantioselective entry into the azadirachtin framework through cascade reactions.
Angew Chem Int Ed Engl
; 42(31): 3637-42, 2003 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-12916035
15.
Total synthesis of apoptolidin: construction of enantiomerically pure fragments.
J Am Chem Soc
; 125(50): 15433-42, 2003 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-14664589
16.
Total synthesis of apoptolidin: completion of the synthesis and analogue synthesis and evaluation.
J Am Chem Soc
; 125(50): 15443-54, 2003 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-14664590