RESUMO
OBJECTIVE: To assess whether the retention rate of certolizumab pegol (CZP) was longer than that of other tumour necrosis factor inhibitors (TNFi) based on baseline rheumatoid factor (RF) levels. METHODS: Longitudinal, retrospective and multicentre study including patients with RA who were treated with any TNFi (monoclonal antibodies (mAB), etanercept (ETA) or CZP). Log-rank test and Cox regressions were conducted to evaluate the retention rate in the three groups according to the level of RF, with the third quartile of the baseline levels used as cut-off: <200 (Assuntos
Artrite Reumatoide
, Inibidores do Fator de Necrose Tumoral
, Humanos
, Estudos Retrospectivos
, Inibidores do Fator de Necrose Tumoral/uso terapêutico
, Fator Reumatoide
, Resultado do Tratamento
, Artrite Reumatoide/tratamento farmacológico
, Certolizumab Pegol/uso terapêutico
, Etanercepte/uso terapêutico
, Anticorpos Monoclonais/uso terapêutico
Assuntos
Articulação do Tornozelo/patologia , Doença de Erdheim-Chester/diagnóstico , Artropatias/diagnóstico , Tíbia/patologia , Articulação do Tornozelo/diagnóstico por imagem , Artralgia/etiologia , Diagnóstico Diferencial , Feminino , Humanos , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Cintilografia , Tomografia Computadorizada por Raios XAssuntos
Síndromes de Compressão Nervosa/diagnóstico , Neuropatia Tibial/diagnóstico , Idoso , Feminino , Pé , HumanosRESUMO
El síndrome de Bertolotti fue descrito en 1917. Se debe a una anormalidad anatómica congénita y se define por la presencia de una megaapófisis transversa, que conlleva una alteración en la transición lumbosacra. Puede generar dolor por afectación de diversas estructuras: neoarticulación lumbosacra, artrosis facetaria del lado contralateral, lumbociatalgia, dolor discogénico o dolor sacroilíaco. Se caracteriza por un dolor lumbar bajo, con una exploración física normal. Según algunos estudios la incidencia es elevada (entre 7 y 20%). El tratamiento inicial debe ser conservador, si bien existen alternativas intervencionistas
Bertolotti's syndrome was first described in 1917. It is due to a congenital anatomical abnormality, and is defined by the presence of a transverse mega-apophysis, which entails an alteration in the lumbosacral transition. It can cause pain due to involvement of various structures: lumbosacral neo-articulation, contralateral facet arthrosis, sciatica, discogenic, or sacroiliac pain. It is characterised by low back pain, with a normal physical examination. According to some studies, the incidence is high (between 7% and 20%). Initial treatment should be conservative, while there are interventionist alternatives