Detalhe da pesquisa
1.
Differential inactivation of polymorphic variants of human O6-alkylguanine-DNA alkyltransferase.
Biochem Pharmacol
; 75(3): 618-26, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17996846
2.
Inactivation of O(6)-alkylguanine-DNA alkyltransferase by folate esters of O(6)-benzyl-2'-deoxyguanosine and of O(6)-[4-(hydroxymethyl)benzyl]guanine.
J Med Chem
; 50(21): 5193-201, 2007 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-17880193
3.
Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.
J Clin Oncol
; 23(28): 7178-87, 2005 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16192602
4.
Role of GADD34 in modulation of cisplatin cytotoxicity.
Biochem Pharmacol
; 71(3): 239-47, 2006 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-16325149
5.
Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma.
J Clin Oncol
; 20(9): 2277-83, 2002 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-11980998
6.
Beta-glucuronidase-cleavable prodrugs of O6-benzylguanine and O6-benzyl-2'-deoxyguanosine.
J Med Chem
; 48(1): 256-61, 2005 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-15634019
7.
Role of glutathione and nucleotide excision repair in modulation of cisplatin activity with O6-benzylguanine.
Cancer Chemother Pharmacol
; 55(4): 333-342, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15723259
8.
Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase with O6-benzylguanine or O6-benzyl-2'-deoxyguanosine.
Clin Cancer Res
; 9(10 Pt 1): 3801-7, 2003 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-14506174
9.
Enhancement of platinum-induced cytotoxicity by O6-benzylguanine.
Mol Cancer Ther
; 2(7): 633-40, 2003 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12883036
10.
O6-benzylguanine-mediated enhancement of chemotherapy.
Mol Cancer Ther
; 1(11): 943-8, 2002 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-12481416
11.
Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations.
Mol Cancer Ther
; 3(9): 1127-35, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15367707
12.
2-amino-O4-benzylpteridine derivatives: potent inactivators of O6-alkylguanine-DNA alkyltransferase.
J Med Chem
; 47(15): 3887-91, 2004 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15239666
13.
Differences in the rate of repair of O6-alkylguanines in different sequence contexts by O6-alkylguanine-DNA alkyltransferase.
Chem Res Toxicol
; 20(12): 1966-71, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17975884
14.
A bifunctional DNA repair protein from Ferroplasma acidarmanus exhibits O6-alkylguanine-DNA alkyltransferase and endonuclease V activities.
Proc Natl Acad Sci U S A
; 102(10): 3617-22, 2005 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-15731349
15.
Effect of cell cycle inhibition on Cisplatin-induced cytotoxicity.
J Pharmacol Exp Ther
; 312(1): 206-13, 2005 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-15304523
16.
Mutagenesis by O(6)-[4-oxo-4-(3-pyridyl)butyl]guanine in Escherichia coli and human cells.
Chem Res Toxicol
; 15(2): 165-9, 2002 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-11849042
17.
Repair of oligodeoxyribonucleotides by O(6)-alkylguanine-DNA alkyltransferase.
Biochemistry
; 41(27): 8689-97, 2002 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-12093287
18.
The repair of the tobacco specific nitrosamine derived adduct O6-[4-Oxo-4-(3-pyridyl)butyl]guanine by O6-alkylguanine-DNA alkyltransferase variants.
Chem Res Toxicol
; 17(3): 424-34, 2004 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15025514