Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Selpercatinib: First approved selective RET inhibitor.

Oliveira, Larissa C B; Mulligan, Lois M.

Cell ; 186(8): 1517, 2023 04 13.

Artigo em Inglês | MEDLINE | ID: mdl-37059058

2.

Comprehensive immunohistochemical analysis of RET, BCAR1, and BCAR3 expression in patients with Luminal A and B breast cancer subtypes.

Pavanelli, Ana Carolina; Mangone, Flavia Rotea; Yoganathan, Piriya; Bessa, Simone Aparecida; Nonogaki, Suely; de Toledo Osório, Cynthia A B; de Andrade, Victor Piana; Soares, Iberê Cauduro; de Mello, Evandro Sobrosa; Mulligan, Lois M; Nagai, Maria Aparecida.

Breast Cancer Res Treat ; 192(1): 43-52, 2022 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-35031902

3.

Selective RET Kinase Inhibitors and Lung Cancer.

Mulligan, Lois.

N Engl J Med ; 389(20): 1913-1916, 2023 Nov 16.

Artigo em Inglês | MEDLINE | ID: mdl-37966290

4.

Differential recruitment of E3 ubiquitin ligase complexes regulates RET isoform internalization.

Hyndman, Brandy D; Crupi, Mathieu J F; Peng, Susan; Bone, Leslie N; Rekab, Aisha N; Lian, Eric Y; Wagner, Simona M; Antonescu, Costin N; Mulligan, Lois M.

J Cell Sci ; 130(19): 3282-3296, 2017 Oct 01.

Artigo em Inglês | MEDLINE | ID: mdl-28794017

5.

Germline ESR2 mutation predisposes to medullary thyroid carcinoma and causes up-regulation of RET expression.

Smith, Joel; Read, Martin L; Hoffman, Jon; Brown, Rachel; Bradshaw, Beth; Campbell, Christopher; Cole, Trevor; Navas, Johanna Dieguez; Eatock, Fiona; Gundara, Justin S; Lian, Eric; Mcmullan, Dom; Morgan, Neil V; Mulligan, Lois; Morrison, Patrick J; Robledo, Mercedes; Simpson, Michael A; Smith, Vicki E; Stewart, Sue; Trembath, Richard C; Sidhu, Stan; Togneri, Fiona S; Wake, Naomi C; Wallis, Yvonne; Watkinson, John C; Maher, Eamonn R; McCabe, Christopher J; Woodward, Emma R.

Hum Mol Genet ; 25(9): 1836-45, 2016 05 01.

Artigo em Inglês | MEDLINE | ID: mdl-26945007

6.

Distinct Temporal Regulation of RET Isoform Internalization: Roles of Clathrin and AP2.

Crupi, Mathieu J F; Yoganathan, Piriya; Bone, Leslie N; Lian, Eric; Fetz, Andrew; Antonescu, Costin N; Mulligan, Lois M.

Traffic ; 16(11): 1155-73, 2015 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-26304132

7.

Loss of Tumour Suppressor TMEM127 Drives RET-mediated Transformation Through Disrupted Membrane Dynamics.

Walker, Timothy J; Reyes-Alvarez, Eduardo; Hyndman, Brandy D; Sugiyama, Michael G; Oliveira, Larissa C B; Rekab, Aisha N; Crupi, Mathieu J F; Cabral-Dias, Rebecca; Guo, Qianjin; Dahia, Patricia L M; Richardson, Douglas S; Antonescu, Costin N; Mulligan, Lois M.

bioRxiv ; 2024 Apr 03.

Artigo em Inglês | MEDLINE | ID: mdl-37425958

8.

Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamics.

Walker, Timothy J; Reyes-Alvarez, Eduardo; Hyndman, Brandy D; Sugiyama, Michael G; Oliveira, Larissa C B; Rekab, Aisha N; Crupi, Mathieu J F; Cabral-Dias, Rebecca; Guo, Qianjin; Dahia, Patricia L M; Richardson, Douglas S; Antonescu, Costin N; Mulligan, Lois M.

Elife ; 122024 Apr 30.

Artigo em Inglês | MEDLINE | ID: mdl-38687678

9.

Multiple functional effects of RET kinase domain sequence variants in Hirschsprung disease.

Hyndman, Brandy D; Gujral, Taranjit S; Krieger, Jonathan R; Cockburn, Jessica G; Mulligan, Lois M.

Hum Mutat ; 34(1): 132-42, 2013 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-22837065

10.

TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation.

Guo, Qianjin; Cheng, Zi-Ming; Gonzalez-Cantú, Hector; Rotondi, Matthew; Huelgas-Morales, Gabriela; Ethiraj, Purushoth; Qiu, Zhijun; Lefkowitz, Jonathan; Song, Wan; Landry, Bethany N; Lopez, Hector; Estrada-Zuniga, Cynthia M; Goyal, Shivi; Khan, Mohammad Aasif; Walker, Timothy J; Wang, Exing; Li, Faqian; Ding, Yanli; Mulligan, Lois M; Aguiar, Ricardo C T; Dahia, Patricia L M.

Cell Rep ; 42(9): 113070, 2023 09 26.

Artigo em Inglês | MEDLINE | ID: mdl-37659079

11.

Evaluating Cell Membrane Localization and Intracellular Transport of Proteins by Biotinylation.

Reyes-Alvarez, Eduardo; Walker, Timothy J; Mulligan, Lois M.

Methods Mol Biol ; 2508: 197-209, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-35737242

12.

Progress and potential impact of RET kinase targeting in cancer.

Mulligan, Lois M.

Expert Rev Proteomics ; 13(7): 631-3, 2016 07.

Artigo em Inglês | MEDLINE | ID: mdl-27337654

13.

Direct visualization of vesicle maturation and plasma membrane protein trafficking.

Richardson, Douglas S; Mulligan, Lois M.

J Fluoresc ; 20(1): 401-5, 2010 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-19823924

14.

RET-mediated gene expression pattern is affected by isoform but not oncogenic mutation.

Hickey, Jessica G; Myers, Shirley M; Tian, Xuefei; Zhu, Shu Jun; V Shaw, Julie L; Andrew, Scott D; Richardson, Douglas S; Brettschneider, Julia; Mulligan, Lois M.

Genes Chromosomes Cancer ; 48(5): 429-40, 2009 May.

Artigo em Inglês | MEDLINE | ID: mdl-19226610

15.

RET isoforms contribute differentially to invasive processes in pancreatic ductal adenocarcinoma.

Lian, Eric Y; Hyndman, Brandy D; Moodley, Serisha; Maritan, Sarah M; Mulligan, Lois M.

Oncogene ; 39(41): 6493-6510, 2020 10.

Artigo em Inglês | MEDLINE | ID: mdl-32884116

16.

RET isoform-specific interaction with scaffold protein Ezrin promotes cell migration and chemotaxis in lung adenocarcinoma.

Moodley, Serisha; Lian, Eric Y; Crupi, Mathieu J F; Hyndman, Brandy D; Mulligan, Lois M.

Lung Cancer ; 142: 123-131, 2020 04.

Artigo em Inglês | MEDLINE | ID: mdl-32146264

17.

A gain-of-functional screen identifies the Hippo pathway as a central mediator of receptor tyrosine kinases during tumorigenesis.

Azad, Taha; Nouri, Kazem; Janse van Rensburg, Helena J; Maritan, Sarah M; Wu, Liqing; Hao, Yawei; Montminy, Tess; Yu, Jihang; Khanal, Prem; Mulligan, Lois M; Yang, Xiaolong.

Oncogene ; 39(2): 334-355, 2020 01.

Artigo em Inglês | MEDLINE | ID: mdl-31477837

18.

GGA3-mediated recycling of the RET receptor tyrosine kinase contributes to cell migration and invasion.

Crupi, Mathieu J F; Maritan, Sarah M; Reyes-Alvarez, Eduardo; Lian, Eric Y; Hyndman, Brandy D; Rekab, Aisha N; Moodley, Serisha; Antonescu, Costin N; Mulligan, Lois M.

Oncogene ; 39(6): 1361-1377, 2020 02.

Artigo em Inglês | MEDLINE | ID: mdl-31645646

19.

Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2B.

Gujral, Taranjit S; Singh, Vinay K; Jia, Zongchao; Mulligan, Lois M.

Cancer Res ; 66(22): 10741-9, 2006 Nov 15.

Artigo em Inglês | MEDLINE | ID: mdl-17108110

20.

65 YEARS OF THE DOUBLE HELIX: Exploiting insights on the RET receptor for personalized cancer medicine.