Detalhe da pesquisa
1.
Effects of Spermine Synthase Deficiency in Mesenchymal Stromal Cells Are Rescued by Upstream Inhibition of Ornithine Decarboxylase.
Int J Mol Sci
; 25(5)2024 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38473716
2.
Ornithine decarboxylase, the rate-limiting enzyme of polyamine synthesis, modifies brain pathology in a mouse model of tuberous sclerosis complex.
Hum Mol Genet
; 29(14): 2395-2407, 2020 08 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32588887
3.
Expanded Potential of the Polyamine Analogue SBP-101 (Diethyl Dihydroxyhomospermine) as a Modulator of Polyamine Metabolism and Cancer Therapeutic.
Int J Mol Sci
; 23(12)2022 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35743239
4.
Renal Transcriptome and Metabolome in Mice with Principal Cell-Specific Ablation of the Tsc1 Gene: Derangements in Pathways Associated with Cell Metabolism, Growth and Acid Secretion.
Int J Mol Sci
; 23(18)2022 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36142537
5.
Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy.
J Biol Chem
; 295(19): 6263-6277, 2020 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32139506
6.
(R,R)-1,12-Dimethylspermine can mitigate abnormal spermidine accumulation in Snyder-Robinson syndrome.
J Biol Chem
; 295(10): 3247-3256, 2020 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31996374
7.
Metabolomic studies identify changes in transmethylation and polyamine metabolism in a brain-specific mouse model of tuberous sclerosis complex.
Hum Mol Genet
; 27(12): 2113-2124, 2018 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29635516
8.
Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia.
J Neuroinflammation
; 17(1): 301, 2020 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33054763
9.
Polyamine catabolism and oxidative damage.
J Biol Chem
; 293(48): 18736-18745, 2018 11 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-30333229
10.
Efficacy and Safety of Curcumin in Treatment of Intestinal Adenomas in Patients With Familial Adenomatous Polyposis.
Gastroenterology
; 155(3): 668-673, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29802852
11.
Targeting polyamine metabolism for cancer therapy and prevention.
Biochem J
; 473(19): 2937-53, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27679855
12.
Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection.
Amino Acids
; 48(10): 2375-88, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27074721
13.
The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines.
Amino Acids
; 46(3): 585-94, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23508577
14.
Polyamine catabolism in carcinogenesis: potential targets for chemotherapy and chemoprevention.
Amino Acids
; 46(3): 511-9, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23771789
15.
Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis.
Proc Natl Acad Sci U S A
; 108(37): 15354-9, 2011 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-21876161
16.
Impaired polyamine metabolism causes behavioral and neuroanatomical defects in a mouse model of Snyder-Robinson syndrome.
Dis Model Mech
; 17(6)2024 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38463005
17.
Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes.
Biochem J
; 442(3): 693-701, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22132744
18.
Impaired polyamine metabolism causes behavioral and neuroanatomical defects in a novel mouse model of Snyder-Robinson Syndrome.
bioRxiv
; 2023 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36711956
19.
Identification and Characterization of Novel Small-Molecule SMOX Inhibitors.
Med Sci (Basel)
; 10(3)2022 08 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-36135832
20.
Interrogation of T Cell-Enriched Tumors Reveals Prognostic and Immunotherapeutic Implications of Polyamine Metabolism.
Cancer Res Commun
; 2(7): 639-652, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36052016