Detalhe da pesquisa
1.
Natural Product Bis-Intercalator Depsipeptides as a New Class of Payloads for Antibody-Drug Conjugates.
Bioconjug Chem
; 30(1): 200-209, 2019 01 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30543418
2.
Novel PIKK inhibitor antibody-drug conjugates: Synthesis and anti-tumor activity.
Bioorg Med Chem Lett
; 29(7): 943-947, 2019 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30655215
3.
Establishing in vitro-in vivo correlation for antibody drug conjugate efficacy: a PK/PD modeling approach.
J Pharmacokinet Pharmacodyn
; 45(2): 339-349, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29423862
4.
Development of Fluorophore-Labeled Thailanstatin Antibody-Drug Conjugates for Cellular Trafficking Studies.
Bioconjug Chem
; 28(4): 1041-1047, 2017 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28191936
5.
Development of Solid-Phase Site-Specific Conjugation and Its Application toward Generation of Dual Labeled Antibody and Fab Drug Conjugates.
Bioconjug Chem
; 27(4): 1030-9, 2016 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-26942771
6.
Natural Product Splicing Inhibitors: A New Class of Antibody-Drug Conjugate (ADC) Payloads.
Bioconjug Chem
; 27(8): 1880-8, 2016 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-27412791
7.
Synthesis, molecular editing, and biological assessment of the potent cytotoxin leiodermatolide.
J Am Chem Soc
; 136(44): 15719-29, 2014 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25347620
8.
New cytotoxic benzosuberene analogs. Synthesis, molecular modeling and biological evaluation.
Bioorg Med Chem Lett
; 23(24): 6688-94, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24210503
9.
Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules.
Mol Cancer Ther
; 5(2): 270-8, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16505100
10.
Multivalent peptidic linker enables identification of preferred sites of conjugation for a potent thialanstatin antibody drug conjugate.
PLoS One
; 12(5): e0178452, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28558059
11.
Site Selection: a Case Study in the Identification of Optimal Cysteine Engineered Antibody Drug Conjugates.
AAPS J
; 19(4): 1123-1135, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28439809
12.
HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.
Cancer Res
; 63(8): 1838-45, 2003 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12702571
13.
Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads.
ACS Med Chem Lett
; 7(11): 999-1004, 2016 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27882198
14.
Optimization of Tubulysin Antibody-Drug Conjugates: A Case Study in Addressing ADC Metabolism.
ACS Med Chem Lett
; 7(11): 977-982, 2016 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27882194
15.
2-(Quinazolin-4-ylamino)-[1,4]benzoquinones as covalent-binding, irreversible inhibitors of the kinase domain of vascular endothelial growth factor receptor-2.
J Med Chem
; 48(24): 7560-81, 2005 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16302797
16.
MAC-321, a novel taxane with greater efficacy than paclitaxel and docetaxel in vitro and in vivo.
Mol Cancer Ther
; 2(9): 873-84, 2003 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-14555706
17.
Cells resistant to HTI-286 do not overexpress P-glycoprotein but have reduced drug accumulation and a point mutation in alpha-tubulin.
Mol Cancer Ther
; 3(10): 1319-27, 2004 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-15486199
18.
Tumor cells chronically treated with a trastuzumab-maytansinoid antibody-drug conjugate develop varied resistance mechanisms but respond to alternate treatments.
Mol Cancer Ther
; 14(4): 952-63, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25646013
19.
Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]- N(1),3-dimethyl-L-valinamide (HTI-286).
J Med Chem
; 47(19): 4774-86, 2004 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-15341492
20.
Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications.
J Med Chem
; 57(24): 10527-43, 2014 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25431858