RESUMO
Regional and neuraxial anesthesia can provide a safer perioperative experience, greater satisfaction, reduced opioid consumption, and reduction of pain, while minimizing side effects. Ultrasound technology has aided clinicians in depositing local anesthetic medication in precise proximity to targeted peripheral nerves. There are a plethora of adjuvants that have been utilized to prolong local anesthetic actions and enhance effects in peripheral nerve blocks. This manuscript describes the current state of the use of adjuncts, e.g., dexmedetomidine, dexamethasone, clonidine, epinephrine, etc., in regional anesthesia. Additionally, evidence behind dosing and block prolongation is summarized along with patient outcomes, adverse effects, and future directions.
Assuntos
Anestesia por Condução/métodos , Anestésicos Locais/administração & dosagem , Bloqueio Nervoso Autônomo/métodos , Dor Pós-Operatória/prevenção & controle , Assistência Perioperatória/métodos , Analgésicos Opioides/administração & dosagem , Anestesia por Condução/tendências , Bloqueio Nervoso Autônomo/tendências , Quimioterapia Combinada , Humanos , Assistência Perioperatória/tendênciasRESUMO
Follow my lead! NSC 670224, previously shown to be toxic to Saccharomyces cerevisiae at low micromolar concentrations, potentially acts via a mechanism of action related to that of tamoxifen (NSC 180973), breast cancer drug. The structure of NSC 670224, previously thought to be a 2,4-dichloro arene, was established as the 3,4-dichloro arene, and a focused library of analogues were synthesized and biologically evaluated.